3068-30-2Relevant articles and documents
The synthesis and radiolabeling of novel markers of tissue hypoxia of the iodinated azomycin nucleoside class
Schneider,Engelhardt,Stobbe,Fenning,Chapman
, p. 541 - 557 (2007/10/03)
Seven second-generation hypoxic markers of the iodinated azomycin nucleoside class have been synthesized and tested for hypoxia marking activity with tumor cells in vitro and in vivo. β-D-lodoazomycin galactoside (IAZG) and β-D-lodoazomycin xylopyranoside (IAZXP) demonstrated superior hypoxia marking properties relative to IAZA because of their higher water solubilities, rapid plasma clearance rates from tumor-bearing mice and maximum tumor/blood (T/B) and tumor/muscle (T/M) ratios. Our studies with animal tumor models show that T/B or T/M ratios of these markers determined by scintigraphy or planar imaging can predict for the relative degree of tumor hypoxia and for tumor radioresistance.
TRIMETHYLSILYL BROMIDE AS A MILD, STEREOSELECTIVE ANOMERIC BROMINATING AGENT
Gillard, John W.,Israel, Mervyn
, p. 513 - 516 (2007/10/02)
Stereoselective bromination of anomeric glycosyl acetates was achieved with trimethylsilyl bromide under mild conditions in the presence of various protecting groups commonly employed in carbohydrate chemistry.
