3354-39-0

Upstream product

• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 35659-69-9 dimethyl-[1,2]dithiol-3-one 
• 75-85-4 tert-Amyl alcohol 
• 513-35-9 2-methyl-but-2-ene 
• 5837-78-5 Ethyl tiglate 
• 2051-04-9 diisoamyl disulfide 
• 22428-91-7 2-methyl-3-oxobutanal 
• 3070-65-3 ethyl 2-methylenebutyrate 
• 590-86-3 isovaleraldehyde 
• 151323-89-6 2-Methyl-3-oxo-dithiobutyric acid 
• 563-45-1 3-Methyl-1-butene 
• 544-02-5 diisopentyl sulfide 
• 112-51-6 diamyl disulfide 
• 89487-71-8 3,4-dichloro-3-methyl-butan-2-one 

Downstream Products

• 91902-50-0 5-(4-methoxy-trans-styryl)-4-methyl-[1,2]dithiol-3-thione 
• 62328-28-3 5-(1-[1,3]dithiolan-2-ylidene-ethyl)-2-phenyl-isothiazole-3-thione 
• 62328-31-8 3-methyl-2,5-bis-methylsulfanyl-6-phenyl-6H-7λ⁴-[1,2]dithiolo[5,1-e]isothiazole 
• 135488-90-3 4-Methyl-5-(4-chloro-phenyl vinyl)-1,2-dithiole-3-thione 
• 91570-69-3 4-Methyl-5-(phenyl vinyl)-1,2-dithiole-3-thione 
• 17835-44-8 4,5-diphenyl-3H-1,2-dithiol-3-one 
• 81385-56-0 2,3-Dimethyl-5,6-diphenylthieno<3,2-b>furan 
• 81385-57-1 2-[1-Methyl-2-thioxo-prop-(Z)-ylidene]-5,6-diphenyl-[1,3]dithiin-4-one 

Relevant academic research and scientific papers

1,2-Dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

The enzyme FabH catalyzes the initial step of fatty acid biosynthesis via a type II dissociated fatty acid synthase. The pivotal role of this essential enzyme, combined with its unique structural features and ubiquitous occurrence in bacteria, has made it an attractive new target for the development of antibacterial and antiparasitic compounds. We have searched the National Cancer Institute database for compounds bearing structural similarities to thiolactomycin, a natural product which exhibits a weak activity against FabH. This search has yielded several substituted 1,2-dithiole-3-ones that are potent inhibitors of FabH from both Escherichia coli (ecFabH) and Staphylococcus aureus (saFabH). The most potent inhibitor was 4,5-dichloro-1,2-dithiole-3-one, which had 50% inhibitory concentration (IC50) values of 2 μM (ecFabH) and 0.16 μM (saFabH). The corresponding 3-thione analog exhibited comparable activities. Analogs in which the 4-chloro substituent was replaced with a phenyl group were also potent inhibitors, albeit somewhat less effectively (IC 50 values of 5.7 and 0.98 μM for ecFabH and saFabH, respectively). All of the 5-chlorinated inhibitors were most effective when they were preincubated with FabH in the absence of substrates. The resulting enzyme-inhibitor complex did not readily regain activity after excess inhibitor was removed, suggesting that a slow dissociation occurs. In stark contrast, a series of inhibitors in which the 5-chloro substituent was replaced with the isosteric and isoelectronic trifluoromethyl group were poorer inhibitors (IC50 values typically ranging from 25 to > 100 μM for both ecFabH and saFabH), did not require a preincubation period for maximal activity, and generated an enzyme-inhibitor complex which readily dissociated. Possible modes of binding of 5-chloro-1,2-dithiole-3-ones and 5-chloro-1,2-dithiole-3- thiones with FabH which account for the role of the 5-chloro substituent were considered.

Thionation with the reagent combination of phosphorus pentasulfide and hexamethyldisiloxane

The combination of P4S10 and hexamethyldisiloxane efficiently converts esters, lactones, amides, lactams, and ketones to their corresponding thiono derivatives. In the presence of elemental sulfur, 3-oxoesters are converted to dithiolethiones by this reagent. Yields are comparable to or superior to those obtained with Lawesson's reagent. The method has the advantage that reagent-derived byproducts may be removed by a simple hydrolytic workup or by filtration through silica gel, rather than by chromatography, as required for Lawesson's reagent.

A superior procedure for the conversion of 3-oxoesters to 3H-1,2-dithiole-3-thiones

The combination of P4S10, sulfur, and hexamethyldisiloxane converts 3-oxoesters to 3H-1,2-dithiole-3-thiones in yields generally superior to those obtained with Lawesson's reagent and without the need for chromatography to remove large amounts of phosphorous-containing byproducts. (C) 2000 Elsevier Science Ltd.

Dianions of 3-oxodithioic acids: Preparation and conversion to 3H-1,2-dithiole-3-thiones

Reaction of ketones with CS2 and 2 equivalents of KH in THF-N,N'-dimethylpropyleneurea solution produces the dianions of 3-oxodithioic acids. These dianions are converted in good yield to 3H-1,2-dithiole-3-thiones by the sequential action of hexamethyldisilathiane and an oxidizing agent such as hexachloroethane. (C) 2000 Elsevier Science Ltd.

Synthesis of 3H-1,2-dithiole-3-thiones by a novel oxidative cyclization

Reaction of 3-oxo dithioic acids with a combination of hexamethyldisilathiane and N-chlorosuccinimide in the presence of a catalytic amount of imidazole brings about oxidative ring closure to 3H-1,2-dithiole-3-thiones. Yields vary from poor to good.