3071-70-3Relevant articles and documents
N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections
Critchley, Megan E.,Lawrence, Clare L.,McKenna, Sean T.,Okoh, Adeyi Okoh,Smith, Robert B.,Vishwapathi, Vinod
, (2020/07/21)
In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3-trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2-methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment.
Promising near-infrared non-targeted probes: Benzothiazole heptamethine cyanine dyes
Okoh, Okoh Adeyi,Bisby, Roger H.,Lawrence, Clare L.,Rolph, Carole E.,Smith, Robert B.
, p. 42 - 56 (2014/01/06)
A series of benzothiazole heptamethine cyanine dyes have been synthesized and their photophysical properties evaluated in relation to their structural features. These have been compared against two classical probes of this type: Indocyanine Green (IGC) and New Indocyanine Green (IR-820). Growth inhibitory studies were also performed using a eukaryotic, unicellular organism, fission yeast Schizosaccharomyces pombe. Herein we highlight some potentially interesting candidates with improved fluorescence quantum yields when compared with ICG and IR-820.
CHEMISTRY OF ENOL ETHERS. LXXIX. REACTION OF GLUTACONALDEHYDE ACETALS AND THEIR DERIVATIVES WITH HETEROCYCLIC COMPOUNDS. THE SYNTHESIS OF TRICARBOCYANINE DYES
Makin, S. M.,Kruglikova, R. I.,Shavrygina, O. A.,Kolobova, T. P.,Popova, T. P.,Tagirov, T. K.
, p. 1850 - 1852 (2007/10/02)
The acetal forms of glutaconaldehyde (2,6-dialkoxypyrans, 1,1,5,5-tetralkoxy-2-pentenes, 5,5-dialkoxy-2-pentenals, and 1,3,5,5-tetraalkoxy-1-pentenes) are capable of reacting with the quaternary salts of heterocyclic bases containing an active methyl group in acetic anhydride solution and in the presence of triethylamine with the formation of tricarbocyanine dyes.Syntheses are reported of unsubstituted thio-, indo-, and quinotricarbocyanines and derivatives with various substituents in the polymethine chain.
