307512-24-9

Basic information

• Product Name: 5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE
• Synonyms: OTAVA-BB BB0129720275;AURORA 20385;AKOS MSC-0524;5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE;5-(4-BroMophenyl)thieno[2,3-d]pyriMidin-4(3H)-one;5-(4-bromophenyl)-Thieno[2,3-d]pyrimidin-4(1H)-one;5-(4-bromophenyl)-3H,4H-thieno[2,3-d]pyrimidin-4-one
• CAS NO: 307512-24-9
• Molecular Formula: C₁₂H₇BrN₂OS
• Molecular Weight: 307.17
• Mol File: 307512-24-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE(307512-24-9)
• EPA Substance Registry System: 5-(4-BROMO-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE(307512-24-9)

Safety Data

• Statements: 20/21/22
• Safety Statements: 24/25-36/37
• Hazardous Substances Data: 307512-24-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-white solid

Upstream product

• 99-90-1 para-bromoacetophenone 
• 306934-99-6 2-amino-4-(4-bromo-phenyl)-thiophene-3-carboxylic acid ethyl ester 
• 77287-34-4 formamide 

Downstream Products

• 379241-58-4 C₁₂H₇BrN₂S₂ 
• 457908-38-2 C₁₆H₁₃BrN₂O₂S₂ 
• 457908-74-6 {[5-(4-bromophenyl)thieno[2,3-d]pyrimidin-4-yl]thio}acetic acid 

Relevant articles and documents

Identification of 4-methoxythieno[2,3-d]pyrimidines as FGFR1 inhibitors

Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. Results. In vitro experiments showed that 9 of 23 tested compounds possess inhibitory activity against FGFR1 with IC50 values in the range from 0.9 to 5.6 μM. Conclusions. Nine FGFR1 inhibitors were developed. The mode of compounds binding with the ATP-acceptor site was determined using molecular docking methods and the dependence of the compounds’ activity on the substituents R1, R4 and R5 was evaluated.

THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS

The present invention provides thienopyrimidine compounds which are potasium channels inhibitors. Pharmaceutical compositions comprising the compounds and their use in the treatment of arrhythmia are also provided.