30752-23-9

Usage

Physical state

Colorless to light yellow liquid

Usage

a. Organic synthesis
b. Intermediate for pharmaceuticals and agrochemicals production
c. Reactant in the manufacture of other organic compounds (pharmaceuticals and pesticides)
d. Solvent in various chemical processes

Safety precautions

a. Harmful if swallowed
b. Harmful if inhaled
c. Harmful if in contact with skin
d. Proper safety measures should be followed when handling

InChI:InChI=1/C10H13BrO/c1-8(2)7-12-10-5-3-9(11)4-6-10/h3-6,8H,7H2,1-2H3

Upstream product

• 1126-75-6 (isobutyloxy)benzene 
• 106-41-2 4-bromo-phenol 
• 513-38-2 Isobutyl iodide 
• 78-77-3 Isobutyl bromide 
• 78-83-1 2-methyl-propan-1-ol 

Downstream Products

• 153624-44-3 para-isobutoxyphenylboronic acid 
• 1369026-19-6 C₁₄H₁₇N₃O₂ 
• 1421597-99-0 C₁₆H₂₅BO₃ 
• 1139901-88-4 tert-butyl 2-(3’-cyano-4’-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 
• 144060-53-7 febuxostat 
• 876918-26-2 5-bromo-2-isobutoxy-benzonitrile 
• 30762-00-6 4-isobutoxybenzoic acid 
• 1428418-60-3 4,7-bis(4-isobutoxyphenyl)-2-isobutyl-2H-benzo[d][1,2,3]triazole 

Relevant academic research and scientific papers

Alkyl chain-functionalized hole-transporting domains in zinc(II) dye-sensitized solar cells

FTO/TiO2 electrodes have been functionalized with {Zn(tpyanchor)(tpyancillary)}2+ dyes (tpy = 2,2′:6′,2″-terpyridine) using a stepwise method to sequentially introduce (i) the anchoring ligand tpyanchor (either a dicarboxylic acid or a diphosphonic acid), (ii) Zn2+ ions, and (iii) chromophoric ancillary (4-([2,2′:6′,2″-terpyridin]-4′-yl)-N,N-bis(4-alkoxyphenyl)aniline ligands. A comparison of unmasked and fully masked DSSCs containing representative dyes shows a significant drop in photon-to-current efficiency upon masking. Solid-state absorption spectra of the dye-functionalized electrodes confirm that the intensity of absorption decreases with the steric demands of the ancillary ligand. DSSC measurements show that the {Zn(tpyanchor)(tpyancillary)}2+ dyes give poor photon-to-current efficiencies, values of the short circuit current density (JSC) and the external quantum efficiency (EQE) spectra are consistent with very poor electron injection. Introducing longer alkoxy chains in place of methoxy substituents in the hole-transporting domains in tpyancillary is beneficial, resulting in increased JSC and VOC, although values remain low despite the 'push-pull' design of the sensitizers.

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain

3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced complete Freund's adjuvant (CFA)-induced thermal hyper

ACYL SULFONAMIDE NaV1.7 INHIBITORS

The present disclosure relates to compounds of formula I which inhibit NaV1.7, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

Preparation method of novel liquid crystal display enhancing luminescence agent

The invention discloses a preparation method of a novel liquid crystal display enhancing luminescence agent. Benzotriazole, potassium carbonate, an organic reagent and halogenated isobutene are added dropwise into a reaction kettle and heated, 2H-2-isobutyl benzotriazole is obtained and further subjected to synthesis of 4,7-dibromo-2H-2-isobutyl benzotriazole, and a product is obtained finally through further reaction. One synthesis process route having the advantages of available raw materials, low cost and high yield is finished and the process route is mature and applicable to industrial production; the product is prepared from benzotriazole as the starting material through steps of hydrocarbylation, halogenation, coupling and the like, and can serve as the novel liquid crystal display enhancing luminescence agent to be widely applied to the liquid crystal display industry; the product fills up the blank in domestic series of the products, is not provided with a CAS number yet, but can produce great return and scientific and technological progress if popularized and used in the domestic electronics industry.

Facile one-pot transformation of arenes into aromatic nitriles under metal-cyanide-free conditions

Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were treated with dichloromethyl methyl ether and ZnBr2, and then with molecular iodine and aq. ammonia to give the corresponding aromatic nitriles in good yields. Using this method, febuxostat was efficiently prepared from 4-bromophenol in four steps. The method can be used for the preparation of aromatic nitriles from arenes in one pot under metal-cyanide-free conditions. Various electron-rich arenes could be effectively converted into the corresponding aromatic nitriles in good yields, by treatment with ZnBr2 and dichloromethyl methyl ether, followed by reaction with molecular iodine and aq. ammonia.

ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS

The present invention provides a compound of formula (I):said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP- 13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP- 13. Finally, the present invention also provides a pharmaceutical composition.

INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of microsomal prostaglandin E synthase-1 is desired and/or required, and particularly in the treatment of inflammation.