307553-10-2

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 89-25-8 edaravone 
• 109-77-3 malononitrile 
• 219719-36-5 C₁₇H₁₂Cl₂N₂O 
• 100-63-0 phenylhydrazine 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 141-97-9 ethyl acetoacetate 
• 2972-76-1 2-(2,4-dichlorobenzylidene)malononitrile 

Relevant academic research and scientific papers

Trichloroacetic acid as a solid heterogeneous catalyst for the rapid synthesis of dihydropyrano[2,3-c]pyrazoles under solvent-free conditions

A one-pot, three-component reaction of an aromatic aldehyde, malononitrile and 3-methyl-1-phenyl-2-pyrazolin-5-one in the presence of a catalytic amount of trichloroacetic acid produces a 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4- dihydropyrano[2,3-c]p

Synthesis of Novel Tacrine Analogs as Acetylcholinesterase Inhibitors

In this work, a wide range of novel pyrazolo[4′,3′:5,6]pyrano[2,3-b]quinolin-5-amines were synthesized as tacrine analogs. At first, reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, aromatic aldehydes, and malononitrile gave 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles. Then, reaction of the latter compounds with cyclohexanone led to the formation of the title compounds. Also, they were evaluated for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities. Interestingly, most of them showed good inhibitory activity comparing with rivastigmine as the reference drug.

NaF-catalyzed efficient one-pot synthesis of dihydropyrano[2,3-c]pyrazoles under ultrasonic irradiation via MCR approach

Sodium fluoride was identified as an efficient catalyst for the preparation of series of dihydropyrano [2,3-c]pyrazoles (4a–l) by the three-component condensation of 3-Methyl-1-phenyl-2-pyrazoline-5-one (1), aromatic aldehydes (2) and malononitrile (3) in

Amino acid ionic liquid-based titanomagnetite nanoparticles: An efficient and green nanocatalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles

The amino acid ionic liquid tetrabutylammonium asparaginate (TBAAsp) was immobilized on titanomagnetite (Fe3?xTixO4) nanoparticles in a facile one-pot process using an organosilane compound (TMSP) as spacer. The modified F

Tungstic acid (H4WO5) immobilized on magnetic-based zirconium amino acid metal–organic framework: An efficient heterogeneous Br?nsted acid catalyst for l-(4-phenyl)-2,4-dihydropyrano[2,3c]pyrazole derivatives preparation

A new magnetic nanocatalyst based on the immobilization of tungstic acid onto new design robust, cost-effective, green, and scalable zirconium-L-aspartate amino acid metal–organic framework (MOF)-grafted L-(+)-tartaric acid stabilized magnetite nanopartic

Greener approach towards the facile synthesis of 1,4-dihydropyrano[2,3-c]pyrazol-5-yl cyanide derivatives at room temperature

This report describes triethylammonium acetate (TEAA) ionic liquid catalyzed one pot synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles by the reaction of aromatic aldehyde, malononitrile and 3-methyl-1-phenyl-2-pyrazo

CTACl AS catalyst for four-component, one-pot synthesis of pyranopyrazole derivatives in aqueous medium

An environmentally benign four-component reaction in aqueous medium in the presence of cetyltrimethylammonium chloride (CTACl) has been developed for the synthesis of 6-amino-3-methyl-4-aryl-/1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole- 5-carbonitrile. The

A clean and simple synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1, 4-dihydropyrano[2,3-c]pyrazole in water

A simple and clean method for producing 6-amino-4-aryl-5-cyano-3-methyl-1- phenyl-1,4- dihydropyrano[2,3-c]pyrazole from aromatic aldehyde, malononitrile and 3-methyl-1-phenyl- 2-pyrazolin-5-one catalyzed by hexadecyltrimethylammonium bromide (HTMAB) in w

Zn(ANA)2Cl2 complex as efficient catalyst for the synthesis of dihydropyrano[2,3-c]pyrazoles in aqueous medium via one-pot multicomponent reaction: a green approach

The first example of recyclable Zn(ANA)2Cl2 catalyzed tandem one-pot three-component protocol reaction between aromatic aldehydes, malononitrile, and phenylmethylpyrazolone to furnish 4-substituted-1,4-dihydropyrano[2,3-c]pyrazole-5-

Solvent-free, one-pot synthesis of pyrano[2,3-c]pyrazole derivatives in the presence of KF·2H2O by grinding

A solvent-free, one-pot process for the preparation of 4H-pyrans in the presence of KF · 2H2O by grinding was achieved. Its advantages are easy workup, mild reaction conditions, high yields, and environmental friendliness. Copyright Taylor & Fr