30779-88-5

Upstream product

• 89622-18-4 3-bromo-3-(4'-methoxybenzyl)chroman-4-one 
• 30779-94-3 (E)-3-(4-methoxybenzylidene)chroman-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 118-93-4 o-hydroxyacetophenone 
• 56202-01-8 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-propan-1-one 
• 124-63-0 methanesulfonyl chloride 
• 84289-40-7 3-(4-methoxybenzyl)-chroman-4-one 
• 34000-29-8 [E]-3-(p-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 109-94-4 formic acid ethyl ester 

Relevant academic research and scientific papers

New convenient synthesis of homoisoflavanones and (±)-di-O- methyldihydroeucomin

Upon reaction of 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones (2′-hydroxydihydrochalcones) with dimethylaminodimethoxymethane in boiling toluene, the corresponding 3-benzylchromones are obtained in excellent yields. These latter lead to 3-benzylchroman-4-on

Synthesis and biological activity of (±)-7,3′,4′-trihydroxyhomoisoflavan and its analogs

Acetylcholinesterase (AChE) inhibitors and neurite outgrowth promoters are thought to alleviate the symptoms of degenerative brain disorders, such as Alzheimer's disease. We designed and synthesized a series of homoisoflavonoids based on the structure of natural homoisoflavan isolated from Dracaena cambodiana dragon's blood. The homoisoflavonoids were then evaluated as AChE inhibitors and neurite outgrowth promoters. The catechol structure of the homoisoflavan B rings was important for AChE inhibition, and some of the homoisoflavonoids significantly promoted neurite outgrowth induced by nerve growth factor (NGF).

Palladium-catalyzed double-bond migration in the homoisoflavone system

3-Benzylidene-4-chromanones were converted to 3-benzylchromones in HMPA at 200°C in excellent yields. The reaction was irreversible and efficiently promoted by palladium catalysts in a remarkably shortened reaction time (3 h), compared with the existing p

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective

Homoisoflavones: Part V - Bromination of 3-Benzylchroman-4-ones

Bromination of 3-benzylchroman-4-ones (IIa-e) with cupric bromide or phenyltrimethylammonium perbromide affords the 3-bromo derivatives (IIIa-e) which have been conveniently converted into homoisoflavones (Va-e).) Bromination of IIa-e with N-bromosuccinim