308110-69-2Relevant articles and documents
A novel inhibitor of human telomerase derived from 10h-indolo[3,2-b]quinoline
Caprio, Vittorio,Guyen, Berengere,Opoku-Boahen, Yaw,Mann, John,Gowan, Sharon M.,Kelland, Lloyd M.,Read, Martin A.,Neidle, Stephen
, p. 2063 - 2066 (2000)
The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity agai
Antifungal and antiparasitic indoloquinoline derivates
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Page/Page column 9, (2008/06/13)
A compound having the formula: wherein: R is an electron withdrawing or electron donating moiety; R5 and R10 may be the same or different and are a straight or branched 1-5 carbon or heteroatom chain substituted terminally by a cycloalkyl or aromatic ring, or other structural isomer or complex thereof; n is the position of substitution of R; Z is N—R10, O, S, S═O, CH2 or C═O; y is 1-5 and Q is Z or NH, with the proviso that, where Z is NH, N—CH3, S or O and Rn is H, R5 may not be CH3; as well as quaternary ammonium salts thereof and their use as pharmacological compositions and for methods of treatment.
Substituted indoloquinolines as new antifungal agents.
Ablordeppey, Seth Y,Fan, Pingchen,Li, Shouming,Clark, Alice M,Hufford, Charles D
, p. 1337 - 1346 (2007/10/03)
Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportuni