5625-46-7Relevant articles and documents
-
Mills
, p. 1136 (1979)
-
-
Kawabata,Kinoshita
, p. 49,51 (1975)
-
Thermally induced oxidative decarboxylation of copper complexes of amino acids and formation of strecker aldehyde
Nashalian, Ossanna,Yaylayan, Varoujan A.
, p. 8518 - 8523 (2015/04/22)
In the Maillard reaction, independent degradations of amino acids play an important role in the generation of amino-acid-specific products, such as Strecker aldehydes or their Schiff bases. Such oxidative decarboxylation reactions are expected to be enhan
Absolute rate constants for the formation of nitrogen-centred radicals from chloramines/amides and their reactions with antioxidants
Pattison, David I.,Davies, Michael J.,Asmus, Klaus-Dieter
, p. 1461 - 1467 (2007/10/03)
Pulse radiolysis techniques have been employed to investigate the one-electron reduction of a variety of chloramines and chloramides. These include models for the side-chain of Lys (6-aminohexanoic acid chloramine and α-N-acetyl-Lys chloramine), Gly chloramine, β-alanine chloramine and two models of protein backbone amides, the chloramides of cyclo-(Gly)2 and cyclo-(Ala)2. The molar absorption coefficients and stabilities of these chloramines/amides have been determined. The one-electron reduction of these chloramine/amide species by hydrated electrons occurs with second-order rate constants of the order of 109-1010 M-1 s-1, and results in cleavage of the N-Cl bonds to yield nitrogen-centred radicals and chloride ions (as measured by high performance ion chromatography). The reactivities of the nitrogen-centred radicals have been investigated with the readily oxidisable quenchers, hydroquinone and Trolox. These quenchers were used as models of the in vivo antioxidants, ubiquinol-10 and α-tocopherol, and react with second-order rate constants between 2 × 107 and 1 × 108 M-1 s-1. No evidence was obtained in these pulse radiolysis experiments for a rapid rearrangement of the oxidising nitrogen-centred radicals to reducing carbon-centred radicals, though such reactions have been indicated in previous EPR studies.