308386-35-8

Basic information

• Product Name: 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: tert-butyl 4-(pyridin-4-yloxy)piperidine-1-carboxylate
• CAS NO: 308386-35-8
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.35
• Mol File: 308386-35-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 391.4±32.0 °C(Predicted)
• Appearance: /
• Density: 1.125±0.06 g/cm3(Predicted)
• PKA: 6.47±0.10(Predicted)
• CAS DataBase Reference: 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester(308386-35-8)
• EPA Substance Registry System: 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester(308386-35-8)

Safety Data

• Hazardous Substances Data: 308386-35-8(Hazardous Substances Data)

Upstream product

• 7379-35-3 4-chlorpyridine hydrochloride 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 626-61-9 4-Chloropyridine 
• 626-64-2 pyridin-4-ol 

Downstream Products

• 845305-82-0 1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide 
• 490030-37-0 4-piperidin-4-yloxypyridine hydrochloride 
• 442198-30-3 (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide 
• 333990-00-4 1-Acetyl-N-(3-chlorophenyl)-N-[3-[4-(4-pyridinyloxy)-1-piperidinyl]propyl]-4-piperidinecarboxamide Trifluoroacetate 
• 845305-83-1 1,1-dimethylethyl 4-(4'-piperidinyloxy)-1-piperidinecarboxylate 

Relevant articles and documents

A two-step procedure for the preparation of mono-protected bis-N-heterocyclic alkyl ether systems

A two-step convenient sequence for the synthesis of previously inaccessible mono-Boc-protected bis-N-heterocyclic alkyl substituted ether derivatives 4 is described. Mitsunobu protocol was applied to the preparation of pyridinyl ether precursor 5. The reduction of the electron rich pyridinyl system 5 has been achieved catalytically using the combination of PtO2-H2SO4 or PtO2-pTsOH under a hydrogen atmosphere maintained by a gas balloon at ambient temperature.

BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE

The disclosure provides BRD9 bifunctional compounds of Formula (A) or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodoma in-containing protein 9 (BRD9)

N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)BENZAMIDE DERIVATIVES

The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.