4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 308386-35-8
• Molecular Formula: C15H22 N2 O3
• Molecular Weight: 278.351
• Hs Code.: 2933990090
• Mol file: 308386-35-8.mol

Synonyms:1-tert-Butoxycarbonyl-4-(4-pyridinyloxy)piperidine;4-[(Pyridin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 391.4±32.0 °C(Predicted)
• PKA: 6.47±0.10(Predicted)
• PSA: 51.66000
• Density: 1.125±0.06 g/cm3(Predicted)
• LogP: 2.79780

Purity/Quality:

99% ，98% ^*data from raw suppliers

tert-Butyl 4-(pyridin-4-yloxy)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-(Pyridin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyridin-4-ol (626-64-2,157061-69-3) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate (308386-35-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃;

Reference yield: 79.0%

4-chlorpyridine hydrochloride (7379-35-3) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate (308386-35-8)

Guidance literature:

4-chlorpyridine hydrochloride; With sodium hydride; In dimethyl sulfoxide; at 70 ℃; for 0.916667h; Inert atmosphere;

t-butyl 4-hydroxy piperidine-1-carboxylate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0028-1088154

Reference yield:

4-Chloropyridine (626-61-9) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-(4'-pyridinyloxy)-1-piperidinecarboxylate (308386-35-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

pyridin-4-ol

t-butyl 4-hydroxy piperidine-1-carboxylate

4-Chloropyridine

4-chlorpyridine hydrochloride

Downstream raw materials:

1-benzyl-4-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)pyridin-1-ium bromide

4-piperidin-4-yloxypyridine hydrochloride

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

1-Acetyl-N-(3-chlorophenyl)-N-[3-[4-(4-pyridinyloxy)-1-piperidinyl]propyl]-4-piperidinecarboxamide Trifluoroacetate

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