845305-82-0Relevant academic research and scientific papers
BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY
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, (2021/04/23)
Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
A practical synthesis of differentially protected 4,4′-dipiperidinyl ethers: Novel ligands of pharmaceutical interest
Bailey, James M.,Bruton, Gordon,Huxley, Anthony,Johnstone, Vicky,Milner, Peter H.,Orlek, Barry S.,Stemp, Geoffrey
experimental part, p. 1051 - 1054 (2009/09/06)
An efficient four-step synthesis (requiring no purification) of Boc-protected 4,4′-dipiperidinyl ethers is described. Georg Thieme Verlag Stuttgart.
SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS
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Page/Page column 18, (2010/02/10)
The present invention relates to novel piperidine ether derivatives having affinity for the histamine H3 receptor, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
