30887-61-7

Upstream product

• 616-79-5 2-amino-5-nitro-benzoic acid 
• 98-88-4 benzoyl chloride 
• 16062-68-3 6-nitro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 
• 62-53-3 aniline 
• 6942-36-5 methyl 2-bromo-5-nitrobenzoate 
• 1527-91-9 N-phenylbenzamidine 

Relevant academic research and scientific papers

From Methaqualone and Beyond: Structure - Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA

Methaqualone (2-methyl-3-(o-tolyl)-quinazolin-4(3H)-one, MTQ) is a moderately potent positive allosteric modulator (PAM) of GABAA receptors (GABAARs). In a previous structure-activity relationship (SAR) study probing the importance of 2- and 3-substituent

Synthesis of quinazolin-4(3 H)-ones via amidine N-arylation

Pyrido[4,3-d]pyrimidin-4(3H)-one (1) was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd 2(dba)3 and Xantphos, followed by cyclization effected with HBTU and subsequent demethylation u