309-91-1

Basic information

• Product Name: N,N-Diethyl-4-fluorobenzenesulfonamide
• Synonyms: N,N-Diethyl-4-fluorobenzenesulfonamide
• CAS NO: 309-91-1
• Molecular Formula: C₁₀H₁₄FNO₂S
• Molecular Weight: 231.2870632
• Mol File: 309-91-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 311.1±44.0 °C(Predicted)
• Appearance: /
• Density: 1.203±0.06 g/cm3(Predicted)
• PKA: -5.05±0.70(Predicted)
• CAS DataBase Reference: N,N-Diethyl-4-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diethyl-4-fluorobenzenesulfonamide(309-91-1)
• EPA Substance Registry System: N,N-Diethyl-4-fluorobenzenesulfonamide(309-91-1)

Safety Data

• Hazardous Substances Data: 309-91-1(Hazardous Substances Data)

Usage

General Description

N,N-Diethyl-4-fluorobenzenesulfonamide is a chemical compound that belongs to the class of sulfonamides. It is synthesized by reacting 4-fluorobenzenesulfonyl chloride with diethylamine. N,N-Diethyl-4-fluorobenzenesulfonamide is mainly used as an intermediate in the production of pharmaceuticals. It has potential applications in the field of medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases. Additionally, it may also be used as an intermediate in the synthesis of other organic molecules. It is important to handle this chemical with care, as it may pose hazards if not used properly.

Upstream product

• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 121-44-8 triethylamine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 109-89-7 diethylamine 

Downstream Products

• 30988-93-3 N,N-diethyl-4-hydroxybenzenesulfonamide 
• 1187189-91-8 C₁₉H₂₂BrNO₅S 
• 1225374-90-2 C₁₃H₂₃N₃O₂S 
• 1383479-25-1 CYM 9552 
• 1160182-48-8 C₁₇H₁₈BrNO₄S 
• 86705-31-9 N,N-diethyl-4-mercaptobenzenesulfonamide 
• 1215122-77-2 bis[4,4'-(N,N-diethylbenzenesulfonamido)phenyl]phenylphosphine 

Relevant articles and documents

Nucleophilic aromatic substitution on 4-fluorophenylsulfonamides: Nitrogen, oxygen, and sulfur nucleophiles

Improved conditions are reported for the stoichiometric reaction of nitrogen, oxygen, and sulfur nucleophiles with weakly activated 4-fluorophenylsulfonamides. Georg Thieme Verlag Stuttgart.

Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors

Inhibition of oxidative phosphorylation (OXPHOS) is a promising therapeutic strategy for select cancers that are dependent on aerobic metabolism. Here, we report the discovery, optimization, and structure-activity relationship (SAR) study of a series of n

Eosin Y-Sensitized Photocatalytic Reaction of Tertiary Aliphatic Amines with Arenesulfonyl Chlorides under Visible-Light Irradiation

A mild, practical, and environmentally friendly route to vinyl sulfones and sulfonamides has been developed based on the reaction of aliphatic amines with arenesulfonyl chlorides in the presence of eosin Y as a photocatalyst under visible light. The method permits the selective formation of vinyl sulfones or sulfonamides, depending on the oxidation environment and solvent. A wide range of products were obtained in moderate to good yields under the optimized conditions.