30923-65-0

Basic information

• Product Name: 1-cyclopropyl-3-phenyl-1,3-propanedione
• Synonyms: 1-cyclopropyl-3-phenyl-1,3-propanedione
• CAS NO: 30923-65-0
• Molecular Weight: 188.226
• Mol File: 30923-65-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-cyclopropyl-3-phenyl-1,3-propanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-3-phenyl-1,3-propanedione(30923-65-0)
• EPA Substance Registry System: 1-cyclopropyl-3-phenyl-1,3-propanedione(30923-65-0)

Safety Data

• Hazardous Substances Data: 30923-65-0(Hazardous Substances Data)

Upstream product

• 765-43-5 Cyclopropyl methyl ketone 
• 93-89-0 benzoic acid ethyl ester 
• 2868-37-3 methyl cyclopropylcarboxylate 
• 98-86-2 acetophenone 
• 1083010-55-2 3-cyclopropyl-1-phenylprop-2-yn-1-one 
• 354996-72-8 (1H-benzo[d][1,2,3]triazol-1-yl)(cyclopropyl)methanone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 34650-69-6 1-cyclopropyl-2-phenylethane-1,2-dione 
• 1208127-10-9 5-cyclopropyl-3-phenyl-1H-pyrazole 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Non-metal catalytic method for preparing 1,3-diketone compounds based on acetyenic ketone

The invention discloses a non-metal catalytic method for preparing 1,3-diketone compounds based on acetyenic ketone. The preparation method is a stepwise method or a one-pot method. The stepwise method comprises the following steps: mixing an acetyenic ketone compound I, a nitrogen-containing aromatic compound II and a No.1 base for a reaction, performing separation and purification to obtain an intermediate product, mixing the intermediate product and a No.2 base for a reaction, and performing separation and purification to obtain the product; and the one-pot method comprises the following steps: firstly mixing an acetyenic ketone compound I and a nitrogen-containing aromatic compound II, adding a No.1 base, performing a reaction for a period of time, adding a No.2 base, continuing a reaction for a period of time, and finally performing separation and purification to obtain the product. The method provided by the invention has mild reaction conditions, simple operation and a higher yield, wherein the yield is generally 80% or more, and the method has greater practical application value in drug synthesis.

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high-throughput screening paradigm facilitated hit identification, while structure-based design and multiparameter optimization enabled the development of compounds with potent enzymatic and cell-based inhibition of LDH enzymatic activity. Lead compounds such as 63 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells. Moreover, robust target engagement of LDHA by lead compounds was demonstrated using the cellular thermal shift assay (CETSA), and drug-target residence time was determined via SPR. Analysis of these data suggests that drug-target residence time (off-rate) may be an important attribute to consider for obtaining potent cell-based inhibition of this cancer metabolism target.