30954-71-3

Basic information

• Product Name: Ethanone, 1-(2-amino-5-hydroxyphenyl)- (9CI)
• Synonyms: Ethanone, 1-(2-amino-5-hydroxyphenyl)- (9CI);2-CHLORO-N-(2-CHLOR-4-METHYL-3-PYRIDYL)3-PYRIDINE CABOXAMIDE;1-(2-amino-5-hydroxyphenyl)ethanone;2'-Amino-5'-hydroxyacetophenone
• CAS NO: 30954-71-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Product Categories: ACETYLGROUP
• Mol File: 30954-71-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 157-161℃
• Boiling Point: 359℃
• Flash Point: 171℃
• Appearance: /
• Density: 1.242
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Refractive Index: 1.613
• PKA: 9.40±0.18(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2-amino-5-hydroxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-5-hydroxyphenyl)- (9CI)(30954-71-3)
• EPA Substance Registry System: Ethanone, 1-(2-amino-5-hydroxyphenyl)- (9CI)(30954-71-3)

Safety Data

• Hazardous Substances Data: 30954-71-3(Hazardous Substances Data)

Usage

Preparation

Preparation by catalytic hydrogenation of 5-hydroxy-2-nitroacetophenone in the presence of platinic oxide in methanol (quantitative yield).

InChI:InChI=1/C8H9NO2/c1-5(10)7-4-6(11)2-3-8(7)9/h2-4,11H,9H2,1H3

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 103-90-2 4-acetaminophenol 
• 551-93-9 2-aminoacetophenone 
• 23042-77-5 1-(2-amino-5-methoxy-phenyl)-ethanone 
• 577-59-3 2-acetylnitrobenzene 
• 4127-53-1 3-methylbenzo[c]isoxazole 
• 30879-49-3 1-(5-hydroxy-2-nitrophenyl)ethan-1-one 
• 16714-26-4 1-(2-azido-phenyl)-ethanone 

Relevant articles and documents

Wavelength-dependent photochemistry of acetaminophen in aqueous solutions

The influence of irradiation wavelength and intensity on photochemistry of acetaminophen (APAP) in aqueous solution was investigated by combination of steady-state and laser flash photolysis as well as HPLC and LC-MS. Steady-state irradiation at 254 nm leads to APAP disappearance with the quantum yield 0.0014 and to formation of 1-(2-amino-5-hydroxyphenyl)ethanone (P1) as a main primary photo-Fries product. In opposite the laser excitation at 266 nm leads predominantly to two-photon ionization of APAP with the quantum yield 0.013 (I = 70 mJ/cm2) and to the formation of one main product of phenoxyl radical reactions - N-(3,4-dihydroxyphenyl)acetamide (P5). Steady-state excitation at 282 nm leads to both P1 and P5 products formation indicating competition of photo-Fries and photoionization processes. The wavelength-dependent mechanism of APAP photolysis is proposed and discussed.

Topoisomerase I-mediated antiproliferative activity of 10-substituted and 12-substituted homocamptothecins

Homocamptothecin (hCPT) is an E-ring modified camptothecin (CPT) analogue, which showed pronounced inhibitory activity of topoisomerase I. In search of novel hCPT-type anticancer agents, two series of hCPT derivatives were synthesized and evaluated in vitro against three human tumor cell lines. The results indicated that the 10-substituted hCPT derivatives had a considerably higher cytotoxic activity than the 12-substituted ones. Among the 10-substituted compounds, 8a, 8b, 9b, and 9i showed an equivalent or even more potent activity than the positive control drug topotecan against the lung cancer cell line A-549. Moreover, the hCPT analogues 8a and 8b exhibited a higher topoisomerase I inhibitory activity than CPT at a concentration of 100 μM. Copyright