31029-96-6

Upstream product

• 31841-17-5 N-(4-(2-oxo-2-phenylacetyl)phenyl)acetamide 
• 122-85-0 para-acetamidobenzaldehyde 
• 100-52-7 benzaldehyde 
• 1849-25-8 4-phenylethynylphenylamine 
• 66749-85-7 1-phenyl-2-(phenylimino)ethanone 
• 62-53-3 aniline 
• 98-86-2 acetophenone 
• 101283-78-7 N-(α'-hydroxy-α-oxo-bibenzyl-4-yl)-acetamide 

Downstream Products

• 81381-90-0 α-hydroxy-α-(4-aminophenyl)-α-phenylacetic acid 
• 64946-35-6 4,4'-(3,3'-diphenyl-7,7'-oxy-di-quinoxalin-2-yl)-bis-aniline 
• 81381-93-3 IQNB 
• 81039-78-3 ethyl α-hydroxy-α-(4-aminophenyl)-α-phenylacetate 
• 88000-52-6 4-[(1-Aza-bicyclo[2.2.2]oct-3-yloxycarbonyl)-hydroxy-phenyl-methyl]-benzenediazonium; chloride 
• 81039-90-9 (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate 
• 81039-90-9 (S)-(+)-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate 
• 81039-90-9 (R)-(-)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate 
• 81381-92-2 (S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate 
• 81381-92-2 (R)-(-)-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate 
• 189680-69-1 6-(N,N-Dimethylamino)-4-[4-(1-phenyl-1,2-dioxoethyl-2-yl)anilino]-pyrido[3,4-d]pyrimidine hydrochloride 

Relevant academic research and scientific papers

Metal-Free Iodine-Catalyzed Oxidation of Ynamides and Diaryl Acetylenes into 1,2-Diketo Compounds

Metal-free oxidation of ynamides is described, employing pyridine-N-oxides as oxidants under molecular iodine catalysis. In stark contrast to Br?nsted acid catalysis, iodophilic activation of ynamides diverts the reaction manifold into a dioxygenation pathway. This oxidation is very rapid at room temperature with only 2.5 mol % I2. Furthermore, this protocol could be extended to nonactivated alkynes, such as diarylacetylenes, to deliver various benzil derivatives.

One-Pot Synthesis of p-Amino-Substituted Unsymmetrical Benzils and Benzil Derivatives

An efficient iodine/copper(II) oxide co-promoted direct oxidative coupling of anilines and methyl aryl ketones has been developed for the synthesis of p-amino-substituted unsymmetrical benzils and their iodo-substituted derivatives. The chemoselectivity of the reactions can be easily controlled by adjusting the amount of iodine. This method exhibits good functional group tolerance for various substituents on the aromatic rings of the methyl aryl ketones. A possible mechanism for this reaction has been proposed based on control experiments. A couple of representative quinoxalines were synthesized from the benzil products in order to demonstrate the utility of this approach. (Figure presented.).

Copper-catalyzed aerobic oxygenative cross dehydrogenative coupling of methyl ketones with: Para -C-H of primary anilines

A novel oxygenative cross dehydrogenative coupling of methyl ketones with para-C-H of primary anilines under a copper/oxygen catalytic system is described. This methodology features advantages including readily available starting materials, green oxidant, and broad functional group tolerance.