31122-75-5

Usage

Chemical Properties

Off-White Solid

Uses

Intermediate in the production of Ioxitalamic Acid

Upstream product

• 108-24-7 acetic anhydride 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 554-68-7 triethylamine hydrochloride 
• 31127-80-7 N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide 
• 1187316-80-8 {2-[3-acetylamino-5-(2-tert-butoxycarbonylaminoethylcarbamoyl)-2,4,6-triiodobenzoylamino]ethyl}carbamic acid tert-butyl ester 
• 152401-32-6 5-acetamido-N,N'dimethyl-N,N'-bis[2,2-bis(hydroxymethyl)-3-hydroxypropyl]-2,4,6-triiodoisophthalamide 

Relevant academic research and scientific papers

Novel triiodinated compounds, preparation method thereof and X-ray contrast comprising the same

The present invention relates to a novel tri-iodinated compound, a manufacturing method for the novel tri-iodinated compound, and an X-ray contrast agent comprising the same and, more specifically, to a compound represented by Chemical Formula 1, a manufa

Effect of contrast agent charge on visualization of articular cartilage using computed tomography: Exploiting electrostatic interactions for improved sensitivity

(Chemical Equation Presented) The synthesis and evaluation of a new class of cationic iodinated contrast agents for the imaging of cartilage using computed tomography (CT) are described. In direct comparisons with anionic contrast agents, the cationic contrast agents afforded higher equilibrium concentrations in the articular cartilage of ex vivo rabbit femurs and thus greater imaging sensitivity. Variations in CT intensity across the sample reflected the inhomogeneous distribution of glycosaminoglycans in the tissue as confirmed by histological analysis. We anticipate that this work represents the first step in the development of sensitive, nondestructive CT-based methods to characterize the biochemical properties of cartilage using cationic contrast agents.

DETERMINATION OF KIDNEY FUNCTION

The present invention provides an isotopically labelled marker of formula (I): where R1 -R5 are as defined herein; characterised in that one or more of the H, N, C or O atoms in the compound of formula (I) is replaced with one or more of2H, 13C, 15N, 17O or 18O respectively, methods for using the inventive marker in detecting the presence or absence of a filtration marker in a sample, measuring the rate of glomerular filtration in a subject and/or diagnosing kidney disease and/or damage in a subject.

METHOD FOR ACETYLATING 5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID DERIVATIVE

A method for producing a 5-acetamide-2,4,6-triiodoisophthalic acid derivative comprising acetylating a 5-amino-2,4,6-triiodoisophthalic acid derivative in an organic solvent in the presence of an acid catalyst using acetic anhydride is disclosed. By the convenient method, a 5-acetamide-2,4,6-triiodoisophthalic acid derivative with a high yield and high quality can be provided.

A PROCESS FOR THE PREPARATION OF 5- ACETYL (2,3-DIHYDROXYPROPYL)AMINO]-N,N'-BIS (2,3-DIHYDROXYPROPYL)-2,4,6- TRIIODO-1,3-BENZENEDICARBOXAMIDE

A process for the preparation of 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride in a solvent selected from the group consisting of: straight or branched (C7-C16) hydrocarbons, (C7-C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol dimethyl ether), in the presence of catalytic amounts of a tertiary amine, to give compound (III); step b) is the acetylation reaction of compound (III) with glacial acetic acid both as the solvent and the reagent and thionyl chloride; step c) is the formation of compound (V) by reaction of the compound (IV) with 1-amino-2,3-propanediol, by reaction of compound (IV) in a dipolar aprotic solvent, selected from the group of dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) or N-methyl-pyrrolidinone; step d) is the alkylation of the compound (V) in aqueous solution at basic pH, by addition of a sodium hydroxide-calcium hydroxide mixture, with 3-chloro-1,2-propanediol or epichlorohydrin, at a temperature of 40-90 DEG C.

Process for the preparation of 5-(acetyl(2,3-dihydroxypropyl)amino-N,N-bis(2,3-dihydroxypropyl)-2,4,6-t riiodo

A process for the preparation of 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride in a solvent selected from the group consisting of: straight or branched (C7 -C16) hydrocarbons, (C7 -C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol dimethyl ether), in the presence of catalytic amounts of a tertiary amine, to give compound (III); step b) is the acetylation reaction of compound (III) with glacial acetic acid both as the solvent and the reagent and thionyl chloride; step c) is the formation of compound (V) by reaction of the compound (IV) with 1-amino-2,3-propanediol, by reaction of compound (IV) in a dipolar aprotic solvent, selected from the group of dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) or N-methyl-pyrrolidinone; step d) is the alkylation of the compound (V) in aqueous solution at basic pH, by addition of a sodium hydroxide-calcium hydroxide mixture, with 3-chloro-1,2-propanediol or epichlorohydrin, at a temperature of 40-90° C.

Compounds which can be used in contrast products for radiography

Polyiodinated nonionic compound that have the formula: STR1

Nonionic X-ray contrast agents, compositions and methods

Triiodinated isophthalamide derivatives, useful as X-ray contrast agents, having at least one amide group derived from the amino-alcohol, 3-(N-2-hydroxyethyl)amino-1,2-propanediol, which provides high water solubility and low mammalian toxicity, and methods of preparing them. Methods of preparing 3-(N-2-hydroxyethyl)amino-1,2-propanediol are provided.

N-Triiodobenzoylaminoacyl polyhydroxic amines

Nonionic triiodobenzoyl amino acyl derivatives of polyhydroxy amines. Such amines are useful as nonionic X-ray contrast agents. For Example 2-(3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoyl glycylamino)-2-deoxy-D-glucitol is especially useful in angiography.

Polyiods benzene derivatives and X-ray contrast media containing the same

This invention relates to compounds of the formula: STR1 in which: R1 represents a hydrogen atom or a C1-4 alkyl radical or a C1-4 hydroxyalkyl radical, R2 represents a C1-4 alkyl radical or a C1