312535-85-6

Upstream product

• 64-18-6 formic acid 
• 20878-56-2 2-amino-N-(3,4-dimethoxyphenyl)benzamide 
• 118-92-3 anthranilic acid 
• 6315-89-5 3,4-dimethoxyaniline 
• 149-73-5 trimethyl orthoformate 
• 118-48-9 isatoic anhydride 
• 122-51-0 orthoformic acid triethyl ester 
• 75-91-2 tert.-butylhydroperoxide 

Downstream Products

• 127662-32-2 3-(3,4-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-quinazoline 

Relevant academic research and scientific papers

TBHP as Methyl Source under Metal-Free Aerobic Conditions To Synthesize Quinazolin-4(3H)-ones and Quinazolines by Oxidative Amination of C(sp3)–H Bond

tert-Butyl hydroperoxide (TBHP) served as the methyl source under metal-free aerobic conditions in the oxidative amination of the C(sp3)–H bond to synthesize quinazolin-4(3H)-ones and quinazolines from 2-aminobenzamides and 2-carbonyl-substituted anilines, respectively.

Synthesis, anti-microbial and molecular docking studies of quinazolin-4(3H)-one derivatives

In this work, synthesis, antimicrobial activities and molecular docking studies of some new series of substituted quinazolinone 2a-h and 3a-d were described. Starting form 2- Aminobenzamide derivatives 1, a new series of quinazolinone derivatives has been

Bi(TFA)3-[nbp]FeCl4: a new, efficient and reusable promoter system for the synthesis of 4(3H)-quinazolinone derivatives

4(3H)-Quinazolinones have been synthesized in high to excellent yields through the one-pot condensation of anthranilic acid, trimethyl orthoformate and primary amines in the presence of 5 mol % of Bi(TFA)3 immobilized on [nbp]FeCl4 a

Synthesis and in vitro study of platelet antiaggregant activity of 1,2,3,4-tetrahydroquinazoline derivatives

Some original 3-substituted 1,2,3,4-tetrahydroquinazolines were synthesized. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by the main inducers (ADP, collagen, arachidonic acid), platelet serotonin release reaction and thromboxane A2 synthesis. All these molecules possess an inhibiting power which, compared to that of aspirin in the same conditions, is the same or greater when aggregation is induced by ADP.