3128-32-3

Basic information

• Product Name: 2-Propenoic acid, hydrazide
• Synonyms: 2-Propenoic acid, hydrazide
• CAS NO: 3128-32-3
• Molecular Formula: C₃H₆N₂O
• Molecular Weight: 86.09254
• Mol File: 3128-32-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, hydrazide(3128-32-3)
• EPA Substance Registry System: 2-Propenoic acid, hydrazide(3128-32-3)

Safety Data

• Hazardous Substances Data: 3128-32-3(Hazardous Substances Data)

Usage

General Description

2-Propenoic acid, hydrazide, also known as acryloyl hydrazide, is a chemical compound with the molecular formula C3H6N2O. It is a colorless to light yellow solid and is commonly used as a reagent in organic chemical reactions. It is also used as a crosslinking agent in the production of polymeric materials. Additionally, 2-Propenoic acid, hydrazide is used in the synthesis of pharmaceutical compounds and agrochemicals. It has been studied for its potential use in the development of drugs for the treatment of various diseases. However, it is important to handle this chemical with care, as it may pose health and environmental risks if not used properly.

Synthetic route

acrylic acid cyanomethyl ester (13818-40-1) → acryloyl hydrazine (3128-32-3)

Conditions	Yield
With chloroform; hydrazine hydrate

potassium acrylate (10192-85-5) → acryloyl hydrazine (3128-32-3)

Conditions	Yield
(i) Py, ClCO2Et, CH2Cl2, (ii) N2H4*H2O; Multistep reaction;

acryloyl-ethoxycarbonyl oxide → acryloyl hydrazine (3128-32-3)

Conditions	Yield
With dichloromethane; hydrazine hydrate

ethyl acrylate (140-88-5) → acryloyl hydrazine (3128-32-3)

Conditions	Yield
With hydrazine hydrate In ethanol Microwave irradiation;
With hydrazine hydrate In tetrahydrofuran at 80℃; for 1h;

acryloyl hydrazine (3128-32-3) + 7-diethylamino-9,9-dimethylfluorene-2-carbaldehyde (1208005-62-2) → C23H27N3O

Conditions	Yield
In ethanol at 80℃; Inert atmosphere;	60%

formaldehyd (50-00-0) + acryloyl hydrazine (3128-32-3) → N',N'-dimethylacetohydrazide (6233-04-1)

Conditions	Yield
palladium In water; benzene

acryloyl hydrazine (3128-32-3) + cadmium(II) chloride (10108-64-2) → Cd(CH2CHCONNH2)Cl(H2O)

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Cd-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + iron(III) chloride (7705-08-0) → (Fe(CH2CHCONHNH2)Cl3)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Fe-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + copper diacetate (142-71-2) → Cu(CH2CHCONHNH2)(CH3CO2)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Cu-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + uranyl acetate → UO2(CH2CHCONNH2)2(H2O)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. UO2-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + cobalt(II) chloride (7646-79-9) → Co(CH2CHCONNH2)2(H2O)2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Co-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + copper dichloride → Cu(CH2CHCONNH2)Cl(H2O)

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Cu-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + nickel dichloride → Ni(2+)*CH2CHCONHNH2*2Cl(1-)=Ni(CH2CHCONHNH2)Cl2

Conditions	Yield
With 2,2'-azobisisobutyronitrile In N,N-dimethyl-formamide refluxing anhyd. Ni-salt with acryloyl hydrazine in DMF and 2,2'-azobisisobutyronitrile as initiator for 8 h; poured into a large excess of distilled water containing dilute HCl, filtered, washed with water, dried in a vac. oven at 40°C for several days; elem. anal.;

acryloyl hydrazine (3128-32-3) + pyridine-2-carboxamidine hydrochloride (51285-26-8, 61097-49-2) → 2-(3-vinyl-1H-1,2-4-triazol-5-yl)pyridine

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 80℃; for 1h;

Upstream product

• 13818-40-1 acrylic acid cyanomethyl ester 
• 10192-85-5 potassium acrylate 
• 140-88-5 ethyl acrylate 

Downstream Products

• 6233-04-1 N',N'-dimethylacetohydrazide 

Relevant articles and documents

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