313050-26-9

Upstream product

• 98-86-2 acetophenone 
• 36640-42-3 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde 
• 24310-46-1 4-methoxyacetophenone phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1255084-46-8 C₃₇H₂₇N₃O₄ 
• 1255084-40-2 C₃₆H₂₅N₃O₃ 
• 1373494-65-5 [5-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl](pyridin-4-yl)methanone 
• 1312583-33-7 C₂₅H₁₈N₂O₃ 

Relevant academic research and scientific papers

The chemistry of α,β-ditosyloxy ketones: Hypervalent iodine (III) mediated synthesis of alkynes from α,β-unsaturated carbonyl compounds containing pyrazole moiety

Background: The present study is an effort to extend the utility of the α,β-ditosyloxy chalcone derivatives in establishing the reaction patterns of these compounds which at once was thought that they might behave similar to α,β-dibromo ketones but the re

Novel pyrazole-pyrazoline hybrids endowed with thioamide as antimalarial agents: Their synthesis and 3D-QSAR studies

One of the most viable options to tackle the growing resistance to the antimalarial drugs is hybrid molecules. It involves combination of different scaffolds in one frame that may lead to compounds with diverse biological profiles. In this context, new hybrids of three different scaffolds viz pyrazole, pyrazoline and thiosemicarbazone moiety were incorporated into one single compound and evaluated for their in vitro schizontocidal activity against the CQ-sensitive 3D7 strain of Plasmodium falciparum. Compounds with significant in vitro antimalarial activity were further evaluated for cytotoxicity against VERO cell lines. The best active compound 48 exhibited an IC50 of 1.13 μM. The in vitro results were further validated by quantitative structure-activity relationship (QSAR).

Synthesis and antimicrobial activity of some (3-phenyl-5-(1-phenyl-3-aryl- 1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones: New derivatives of 1,3,5-trisubstituted pyrazolines

A series of (3-phenyl-5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-4,5-dihydro-1H- pyrazol-1-yl)(pyridin-4-yl)methanones was synthesized by condensing suitably substituted chalcones, i.e., 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2- en-1-ones, and isoniazi

Synthesis and antimicrobial screening of some 3-[4-(3-aryl- 1-phenyl-lH-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] and 4-methyl- 3-phenyl-6-[4-(3-aryl- 1-phenyl- lH-pyrazol- 4-yl)-6-aryl-pyridin-2-yl] coumarins

Various 3-[4-(3-ary 1-1 -phenyl-lH-pyrazol-4-yl)-6-ary 1-pyridin- 2-yl] coumarins 4a-l and 4-methyl-3-phenyl-6-[4-(3-aryl-l- pheny 1- l//-pyrazol-4-y l)-6-ary l-pyridin-2-y 1] ooumarins5a-fhave been synthesized by reacting 3-coumarinoylmethyl pyridinium b