313270-24-5

Upstream product

• 126-81-8 dimedone 
• 3695-84-9 methyl benzylidenecyanoacetate 
• 100-52-7 benzaldehyde 
• 105-34-0 methyl 2-cyanoacetate 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 14533-86-9 methyl (E)-2-cyano-3-phenylprop-2-enoate 

Relevant academic research and scientific papers

Organocatalyzed enantioselective synthesis of 2-amino-5-oxo-5,6,7,8- tetrahydro-4H-chromene-3-carboxylates

The organocatalyzed enantioselective synthesis of biologically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate derivatives was achieved using bifunctional cinchona alkaloids as the catalysts. Using quinine thiourea as the catalyst, the t

Synthesis and X-ray crystal structures of polyfunctionalized 4H-chromene derivatives via tricomponent reaction with Knoevenagel adducts as intermediates in aqueous medium

Chromenes and their derivatives are an important class of compounds known for their biological properties. In this study, synthetic methodologies were described to obtain 4H-chromene derivatives. Two routes were investigated, the first being a bicomponent

Synthesis of hybrid perillyl-4H-pyrans. Cytotoxicity evaluation against hepatocellular carcinoma HepG2/C3A cell line

A series of 15 new hybrid perillyl-4H-pyrans compounds was straightforwardly synthesized by a strategy combining the multicomponent reaction and the copper-catalyzed alkyne-azide cycloaddition (CuAAC). The 2-amino-4H-pyrans-3-carbonitrile containing the a

Organocatalyzed Enantioselective Synthesis of 2-Amino-4H-chromene Derivatives

Optically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates, 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles, and 2-amino-8-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles were synthesized. Using cinchona alkaloid-derived bifunctional catalysts, the corresponding 2-amino-4H-chromene derivatives were obtained in high yields and moderate to high ee values (up to 82% ee) from the tandem Michael addition–cyclization reaction between 1,3-cyclohexanediones or 1,2-cyclohexanediones and (E)-3-aryl-2-cyanoacrylate or alkylidene malononitrile derivatives.

Diammonium hydrogen phosphate: An efficient and versatile catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran derivatives in aqueous media

Diammonium hydrogen phosphate was used as a mild, efficient, neutral, and cheap catalyst for the synthesis of various 4H-benzo[b]pyran derivatives via a one-pot, three-component condensation of aromatic aldehydes, active methylene compounds, and dimedone in aqueous media. Copyright Taylor & Francis Group, LLC.

Uncatalyzed reactions in aqueous media: Three-component, one-pot, clean synthesis of tetrahydrobenzo[b]pyran derivatives

The synthesis of various tetrahydrobenzo[b]pyran derivatives has been carried out by means of an uncatalyzed, three-component, one-pot clean condensation of aromatic aldehydes, reactive methylene compounds, and dimidone in aqueous medium. Simple workup, and mild and neutral conditions that give quantitative yields of products in pure form, are the attractive features of this method. CSIRO 2007.

Efficient synthesis of tetrahydrobenzo[b]pyrans under solvent-free conditions at room temperature

A range of tetrahydrobenzo[b]pyrans have been synthesized in very good yields under solvent-free conditions by grinding α-cyanocinnamonitrils or β-cyano-β-carbethoxy styrene and 5,5-dimethyl-1,3-cyclohexanedione in the presence of TEBA as catalyst. The sh

One-pot synthesis of 2-amino-4-aryl-3-carbalkoxy-7,7-dimethyl-5,6,7,8- tetrahydrobenzo[b]pyran derivatives catalyzed by KF/basic Al2O 3 under ultrasound irradiation

Synthesis of 2-amino-4-aryl-3-carbalkoxy-7,7-dimethyl-5-oxo-5,6,7,8- tertrahydrobenzo[b]pyran derivatives was carried out in 81-98% yields by one-pot condensation of aromatic aldehydes with cyanoacetic esters and 5,5-dimethyl-1,3-cyclohexanedione catalyze

A convenient synthesis of 5-oxo-5,6,7,8-tetrahydro-4H-benzo-[b]-pyran derivatives catalyzed by KF-alumina

A series of 5-oxo-5,6,7,8-tetrahydro-4H-benzo-[b]-pyran derivatives were prepared by the reaction of arylmethylidenemalononitriles or 2-cyano-3-aryl-1-acrylate with 5,5-dimethyl-1,3-cyclohexanedione (dimedone) in DMF at room temperature catalyzed by KF-al