189562-46-7

Upstream product

• 67-56-1 methanol 
• 313468-89-2 (2S, 3S)-3-N,N-dibenzylamino-2-acetyloxy-4-phenylbutyronitrile 
• 148692-42-6 (3S)-3-N,N-dibenzylamino-2-oxo-4-phenylbutyric acid methyl ester 

Downstream Products

• 195510-33-9 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanoic acid 

Relevant academic research and scientific papers

Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives

The present invention relates to a process for reacting α-aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active α-aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.

Process for producing norstatin derivatives

This invention to provide a process for producing an optically active threo-phenylnorstatin derivative which does not require a toxic cyanating agent or a costly reagent, or a complicated procedure, and can be practiced on a commercial scale. This inventi