31352-38-2

Upstream product

• 100841-04-1 3-(4-nitrophenoxy)propan-1-amine 
• 904-10-9 N-[3-(4-Nitrophenoxy)propyl]phthalimide 
• 103-90-2 4-acetaminophenol 
• 13094-50-3 1-(3-bromopropoxy)-4-nitrobenzene 
• 864528-96-1 C₉H₁₀N₄O₃ 
• 350-46-9 4-Fluoronitrobenzene 
• 101243-52-1 N-[3-(4-acetylamino-phenoxy)-propyl]-phthalimide 
• 100-02-7 4-nitro-phenol 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 100840-50-4 2-[3-(4-Aminophenoxy)propyl]-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 1567434-05-2 C₂₆H₂₂FN₅O₃ 
• 1567435-99-7 C₁₄H₁₆FN₃O 
• 1613189-33-5 C₄₁H₅₂N₄O₄Si 
• 860032-85-5 5-[(R)-2-(2-{4-[4-(3-amino-propoxy)-phenylamino]-phenyl}-ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one 

Relevant academic research and scientific papers

Discovery of TD-4306, a long-acting β2-agonist for the treatment of asthma and COPD

A multivalent approach focused on amine-based secondary binding groups was applied to the discovery of long-acting inhaled β2-agonists. Addition of amine moieties to the neutral secondary binding group of an existing β2-agonist serie

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors

We designed a series of anilino-indoylmaleimides based on structural elements from literature JAK3 inhibitors 3 and 4, and our lead 5. These new compounds were tested as inhibitors of JAKs 1, 2 and 3 and TYK2 for therapeutic intervention in rheumatoid art