31380-57-1

Usage

Uses

Used in Pharmaceutical Industry:
5-Acetyl-2-indole carboxylic acid is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable component in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
5-Acetyl-2-indole carboxylic acid is used as a key intermediate in organic synthesis, allowing for the creation of a wide range of chemical compounds with diverse applications.
Used in Drug Development:
Due to its potential biological activities and pharmacological properties, 5-Acetyl-2-indole carboxylic acid is used in the research and development of new drugs and therapeutic agents, particularly for its anti-inflammatory and anticancer effects.
Used in Research:
5-Acetyl-2-indole carboxylic acid is utilized in scientific research to study its potential applications and to gain a deeper understanding of its properties and interactions with other compounds.

Upstream product

• 31380-56-0 5-acetyl-1H-indole-2-carboxylic acid ethyl ester 
• 99-92-3 p-aminobenzophenone 
• 127-17-3 2-oxo-propionic acid 
• 97776-06-2 4-acetyl-2-iodoaniline 
• 77069-10-4 ethyl 3-acetyl-1H-indole-2-carboxylate 

Downstream Products

• 1228694-02-7 methyl (S)-5-(benzyloxy)-1-(chloromethyl)-3-(5-acetylindole-2-carbonyl)-1,2-dihydropyrrolo[3,2-e]indole-2-carboxylate 
• 1416246-63-3 1-(2-(4-(4-methoxyphenyl)piperazine-1-carbonyl)-1H-indol-5-yl)ethanone 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO

The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.

Synthesis and evaluation of a series of C5′-substituted duocarmycin SA analogs

The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5′ position of the DNA binding subunit, are described.

Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine

Cost and toxicity problems associated with highly active antiretroviral therapy (HAART) in HIV/AIDS treatment could be alleviated by using designed multiple ligands (DMLs). Dual inhibitors of HIV reverse transcriptase (RT) and integrase (IN) were rationally designed by introducing a diketoacid (DKA) functionality into the tolerant C-5 site of RT inhibitor delavirdine. The resulting compounds all demonstrate good activity against both RT and IN in enzymatic assays and HIV in cell-based assay, whereas their C-7 regioisomers are all inactive in these assays. Balanced activities were observed with C-3 halogenated inhibitors.

CBI analogues of the duocarmycins and CC-1065

An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring substituent effects within the first indole DNA binding subunit is detailed. In general, substitution at the indole C5 position led to cytotoxic potency enhancements that can be ≧1000-fold providing simplified analogues containing a single DNA binding subunit that are more potent (IC50=2-3 pM) than CBI-TMI, duocarmycin SA, or CC-1065. The increases in cytotoxicity correlate well with accompanying increases in the rate and efficiency of DNA alkylation. This effect is more pronounced with the CBI versus DSA or CPI based analogues. Moreover, this effect is largely insensitive to the electronic character of the C5 substituent but is sensitive to the size, rigid length, and shape (sp, sp2, sp3 hybridization) of this substituent consistent with expectation that the impact is due simply to its presence.

Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antivi