31382-86-2

Upstream product

• 98-88-4 benzoyl chloride 
• 59046-22-9 (3-methylpyridin-1-ium-1-yl)amide 
• 6526-37-0 1-(2,4-dinitrophenyl)-3-methylpyridinium chloride 
• 108-99-6 3-Methylpyridine 
• 613-94-5 benzoic acid hydrazide 

Downstream Products

• 104642-66-2 5-methyl-N-(3,6-dihydro-1(2H)-pyridinyl)benzamide 
• 1005135-68-1 5-methyl-2-phenyl-N-benzoyliminopyridinium ylide 
• 340771-06-4 6-methyl-2-phenylpyrazolo[1,5-a]pyridine 
• 85364-59-6 4-methyl-2-phenylpyrazolo<1,5-a>pyridine 
• 1619940-78-1 C₁₉H₁₆N₂O 
• 1619940-79-2 C₁₉H₁₆N₂O 
• 1337985-03-1 2-cyclohexenyl-6-methylpyrazolo[1,5-a]pyridine 
• 1337985-06-4 2-cyclohexenyl-4-methylpyrazolo[1,5-a]pyridine 
• 1219634-39-5 5-methyl-2-(E)-styryl-N-benzoyliminopyridinium ylide 
• 104642-90-2 3-methyl-N-(hexahydropyridinyl)benzamide 

Relevant academic research and scientific papers

Benzoyl peroxide promoted radical ortho-alkylation of nitrogen heteroaromatics with simple alkanes and alcohols

A catalytic amount of benzoyl peroxide (BPO)-initiated cross-dehydrogenative coupling reaction of N-iminopyridine ylides with simple alkanes and alcohols leads to the corresponding 2-alkylpyridines with high regioselectivity in moderate to good yields without an additional reduction step to remove the activated group. A catalytic amount of benzoyl peroxide (BPO)-initiated cross-dehydrogenative coupling reaction of N-iminopyridine ylides with simple alkanes and alcohols has been developed. The strategy allowed convenient access to various 2-alkylpyridines in moderate to good yields without an additional reduction step to remove the activated group.

Synthesis of 2- and 2,3-substituted Pyrazolo[1,5- a ]pyridines: Scope and mechanistic considerations of a domino direct alkynylation and cyclization of n -iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes

Direct functionalization and tandem processes have both received considerable recent interest due to their cost and time efficiency. Herein we report the synthesis of difficult to obtain 2-substituted pyrazolo[1,5-a] pyridines through a tandem palladium-catalyzed/silver-mediated elimination/direct functionalization/cyclization reaction involving N-benzoyliminopyridinium ylides. As such, these biologically important molecules are prepared in an efficient, high-yielding manner, only requiring a two-step sequence from pyridine. Aryl-substituted alkenyl bromides and iodides are effective ylide coupling partners. Mechanistic studies led to the use of terminal alkynes, which extended the scope of the reaction to include alkyl substitution on the unsaturated reactive site. The optimization, scope, and mechanistic considerations of the process are discussed.

Synthesis and pharmacological evaluation of some N- [pyridyl(phenyl)carbonylamino]methyl-1,2,3,6-tetrahydropyridines

Reaction of some plcolines 5 with 1-chloro-2,4-dinitrobenzene (6) in acetone furnished methyl-substituted 2,4-dinitrophenylpyridinium chlorides 7. Further reaction with phenyl(pyridyl)carbonyl hydrazides 8 at room temperature furnished isolable 2,4-dinitr