31408-40-9

Upstream product

• 50-01-1 guanidine hydrochloride 
• 82525-15-3 (Z)-2-(4-Chloro-phenyl)-3-methylsulfanyl-propenal 
• 82525-10-8 1-chloro-4-(2-methylsulfanylvinyl)benzene 
• 405-50-5 p-Fluorophenylacetic acid 
• 252950-06-4 C₁₃H₁₈FN₂⁽¹⁺⁾*ClO₄^(1-) 
• 113-00-8 guanidine nitrate 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 1765-93-1 4-fluoroboronic acid 
• 75175-39-2 2-chloro-5-(4-fluoro phenyl)pyrimidine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1029712-77-3 6-(4-fluorophenyl)-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine 
• 1192312-56-3 C₂₃H₁₉FN₄O₃ 
• 1192312-52-9 C₂₃H₁₉FN₄O₃ 
• 1192312-60-9 C₂₃H₁₉FN₄O₃ 

Relevant academic research and scientific papers

Preparation of 2,5-disubstituted pyrimidines from vinamidinium salts and synthesis of novel disulfane derivatives

Novel pyrimidine derivatives were prepared from the reaction of 2-substituted 1,3-bis(dimethylamino)-trimethinium salts with thiourea or guanidine in the presence of ethyl-diisopropylamine in ethanol at reflux, and also some 5-substituted pyrimidine-2-thi

2-polysubstituted aromatic ring-pyrimidine derivative and preparation and medical application

The invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative, an optical isomer of the derivative or a medically acceptable salt or solvate of the derivative, and application of the compound, the optical isomer of the derivative or the medically acceptable salt or solvate of the derivative in preparing antineoplastic medicine. According to the 2-polysubstituted aromatic ring-pyrimidine derivative, by adopting N-substituted pyridine-2-minopyrimidine as a lead compound obtained based on virtual screening of a structure, a series of brand new small molecule Chk1 inhibitors are designed and synthesized, and a Chk1 kinase inhibitory activity test of a molecular level is conducted on the compound. Experiments prove that the compound is a Chk1 inhibitor with a strong antitumous effect, Chk1 kinase inhibitory activity and a prospect, and new cancer treating medicine, and can be used for treating solid tumor or leukemia related with human or animal cell proliferation. The 2-polysubstituted aromatic ring-pyrimidine derivative has a structure shown in the general formula I.

A general and highly efficient method for the construction of aryl-substituted N-heteroarenes

A general, simple and highly efficient method has been developed for the Pd(OAc)2-catalyzed ligand-free and aerobic Suzuki reaction of N-heteroaryl halides, which is strongly dependent on the molecular structure of solvent. A general, simple and highly efficient method has been developed for the Pd(OAc)2-catalyzed ligand-free and aerobic Suzuki reaction of N-heteroaryl halides including 2-pyridyl bromides, 3-pyridyl bromides, 3-quinolyl bromides, 5-pyrimidyl bromides and 2-pyrazyl chloride, which is strongly dependent on the molecular structure of solvent.

A NEW AND FACILE SYNTHESIS OF 5-ARYLPYRIMIDINES AND 4-ARYLPYRAZOLES

A condensation of 2-aryl-3-(methylthio)acroleins (3a)-(3e), a new masked form of arylmalondialdehydes, with amidines yielded the corresponding 5-arylpyrimidines (4a)-(4k).Similarly, the reaction of 3 with N-substituted hydrazines gave the corresponding 1-