31431-26-2

Usage

Uses

Used in Pharmaceutical Industry:
(4-AMINO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique functional groups and reactivity make it a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
(4-AMINO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE is used as a research compound in the field of organic chemistry. Its distinct structural features and reactivity provide opportunities for studying reaction mechanisms, exploring new synthetic routes, and understanding the influence of functional groups on molecular properties.
Used in Material Science:
(4-AMINO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE is used as a precursor in the development of novel materials with specific properties. Its structural characteristics and reactivity can be exploited to create new materials with potential applications in various industries, such as electronics, coatings, or adhesives.

Upstream product

• 31431-16-0 4-chloro-4'-fluoro-3-nitrobenzophenone 
• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 462-06-6 fluorobenzene 

Downstream Products

• 31430-15-6 methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate 
• 64420-30-0 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]-2-nitrobenzenamine 
• 66938-86-1 (3,4-diaminophenyl)(4-fluorophenyl)ketone 

Relevant academic research and scientific papers

Preparation method of flubendazole

The invention relates to a preparation method of flubendazole. The preparation method comprises the following steps: dropwise adding thionyl chloride into a reaction system taking 4-chloro-3-nitrobenzoic acid and o-dichlorobenzene as solvents, wherein DMF (Dimethyl Formamide) is used as a reaction catalyst; then dropwise adding an acylated reaction solution into a fluorobenzene and aluminum trichloride system and carrying out Friedel-Crafts reaction; adding ammonia water, methane and a Friedel-Crafts product into a closed reactor for carrying out amination reaction; adding aminate, the methaneand a palladium carbon catalyst into a high-pressure hydrogenation reactor for reducing; adding a cyclization agent into a reduced reaction solution from which a catalyst is removed for cyclizing; finally, dropwise adding hydrogen peroxide into the cyclized reaction solution for oxidizing. The preparation method disclosed by the invention has the advantages that firstly, during cyclization reaction, an intermediate has an passivation action of carbonyl, so that the cyclization reaction is smoother and reaction time is greatly shortened; secondly, nitro is reduced by adopting a hydroreductionmethod which has better economic and environment-friendly properties compared with a traditional sulfuration alkaline method; thirdly, the cyclization agent adopts lower-price methyl cyanocarbamate,so that production cost is reduced.

Synthesis and anthelminthic acitivity of alkyl-(5-acyl-1-benzimidazol-2-yl) carbamates

A series of alkyl-(5-acyl-l-H-benzimidazol-2-yl)-carbamates were prepared and screened for anthelminthic activity. Some of them were found to be fully active at low, atoxic oral dose levels against gastro-intestinal nematodes. The activity against Syphacia muris and Strongyloides ratta is indicated. From these studies methyl (5-benzoyl-1-H-benzimidazol-2-yl) carbamate (mebendazole) and methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl]carbamate (flubendazole) were selected for detailed investigation.