31444-62-9Relevant articles and documents
A facile synthesis and application of protoporphyrin derivatives on reducing the tobacco specific N-nitroamines levels of smoke
Tao, Fei Y.,Wang, Chang G.,Ma, Kuo Y.,Li, Dong L.,Tan, Lan L.,Zhang, Ji,Dai, Ya,Yu, Xiao Q.
, p. 309 - 316 (2013)
Two protoporphyrin derivatives were prepared by a facile method using inexpensive hemin as starting material. They were added to cigarette filters to reduce the carcinogenic tobacco specific N-nitroamines (TSNAs), especially toward NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) and NNN (N-nitrosonornicotine) for environment protection and public health. The reduction level of TSNAs was reached to 37.6% from MSS, with greater reductions when more porphyrin was included in the filter. The decrease level for NNK by protoporphyrin derivatives is more effective than NNN. The interaction between protoporphyrin derivatives and TSNAs (NNK and NNN) were investigated by fluorescence spectra and UV-visible titration. The correlation coefficients were 0.978~0.997 and the binding constants was the scope from 1.26 × 103 to 4.04 × 104. The interaction mechanisms between protoporphyrin derivatives and, NNK and NNN are possibly the co-interaction of hydrogen bond binding and strong π-π stacking.
The preparation and some properties of a liposome formulation of 2,4-di(1-methyl-3-hydroxybutyl)deuteroporphyrin IX
Reshetnickov,Zhigal'tsev,Kolomeichuk,Kaplun,Shvets,Zhukova,Karmenyan,Ivanov,Ponomarev
, p. 692 - 699 (2007/10/03)
A liposome preparation of a porphyrin photosensitizer for photodynamic therapy of tumors (PDT) was obtained. The in vitro efficiency of the photosensitizer was enhanced 2.5-fold through the liposome formulation. The composition and some properties of the new preparation were studied. An algorithm for a complex approach to the prediction of photosensitizer efficiencies by model experiments in vitro was developed. This approach is based on the use of two models: the determination of coefficient of distribution between n-octanol and a phosphate buffer, pH 7.4, and the determination of the cytotoxic effect on the culture of CaOv ovarian adenocarcinoma cells.
SYNTHESIS AND STUDY OF THE SPECTRAL PROPERTIES OF DIQUINONE DERIVATIVES OF HEMATOPORPHYRIN IX
Borovkov, V. V.,Gribkov, A. A.,Evstigneeva, R. P.,Struganova, I. A.,Ponomarev, G. V.,et al.
, p. 1059 - 1064 (2007/10/02)
Diquinone derivatives of hematoporphyrin IX with different structures of the quinone fragments were synthesized by the method of mixed anhydrides.The compounds obtained were investigated by UV, IR, PMR, and fluorescence spectroscopy.Pronounced quenching o