31505-87-0

Upstream product

• 87125-04-0 N-{9-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide 
• 3256-14-2 (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-((tetrahydro-2H-pyran-2-yl)oxy)tetrahydrofuran-3-ol 
• 98-88-4 benzoyl chloride 
• 110-87-2 3,4-dihydro-2H-pyran 
• 90742-24-8 2'-O-(tetrahydropyran-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 58-61-7 adenosine 
• 69304-45-6 3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine 

Downstream Products

• 71933-61-4 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁶-benzoyladenosine 
• 74219-87-7 dmtbzCtp(qcl)bzCtp(qcl)BzAt 
• 83435-76-1 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester bis-(5-chloro-quinolin-8-yl) ester 
• 71933-65-8 C₆₆H₆₆ClN₈O₁₇P 
• 189256-22-2 2-(4-Oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 
• 224052-19-1 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 
• 87125-10-8 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester 
• 87125-06-2 6-N-benzoyl-2'-O-tetrahydropyranyl-5'-O-dimethoxytrityladenosine-3'-(p-chlorophenyl-2-cyanoethyl)phosphate 
• 3256-24-4 phosphoric acid adenosin-5'-yl ester uridin-3'-yl ester 

Relevant academic research and scientific papers

Application of the Tetraisopropyldisiloxane-1,3-diyl Group in the Chemical Synthesis of Oligoribonucleotides

The application of the tetraisopropyldisiloxane-1,3-diyl (TIPDSi) group for the large-scale preparation of the key components for the chemical synthesis of oligoribonucleotides by the triester approach is described. The key components, N-benzol-2'-O-tetra

A Convenient Synthesis of the 3'-Terminal Nonaoligoribonucleotide of Rous Sarcoma Virus 35S RNA via the Modified Phosphotriester Approach

The synthesis of oligoribonucleotide UpUpCpApCpCpApCpA via the phosphotriester approach, which is located at the 3'terminus of Rous sarcoma virus 35S RNA, is described. 5'-O-(Dimethoxytrityl)-2'-O-tetrahydropyranyl-N-acylnucleoside 3'-(4-chlorophenyl 5-chloro-8-quinolyl phosphates) were used as the starting materials .Treatment of the fully protected mononucleotides with 2percent p-toluenesulfonic acid afforded the 5'-hydroxyl nucleotides, whereas treatment with syn-pyridine-2-carboxaldoxime to remove the 4-chlorophenyl group gave the phosphodiesters.The fully protected nona mer was prepared by utilizing these deblocking products.The fully protected nonamer was completely deprotected by treatment with zinc chloride, followed by treatment with base and acid, to give the corresponding oligoribonucleotide.