31507-30-9

Upstream product

• 14562-04-0 toluene-4-sulfonic acid cyanomethyl ester 
• 88-75-5 2-hydroxynitrobenzene 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 104990-48-9 2-phenyl-4H-imidazo<2,1-c><1,4>benzoxazine 
• 20916-31-8 2-nitrophenoxyacetanilide 
• 137988-20-6 Acetic acid 3-(2-nitro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 137988-04-6 7-Hydroxy-3-(2-nitro-phenoxy)-chromen-4-one 
• 5735-53-5 1,4-benzoxazine 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 137987-91-8 1-(2,4-Dihydroxy-phenyl)-2-(2-nitro-phenoxy)-ethanone 

Relevant academic research and scientific papers

METHODS FOR PREPARING FUEL ADDITIVES

A method is provided for preparing a fuel additive having the formula: ( l ) The method comprises carrying out the following reactions: (i) addition of an alkylating agent b to starting material a: (a) to form an intermediate c; and (ii) ring closing intermediate c to form fuel additive e.

Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction

We have synthesized bioactive 1,4-disubstituted 1,2,3-triazole analogues containing 2H-1,4-benzoxazin-3-(4H)-one derivatives via 1,3-dipolar cycloaddition in the presence of CuI. All the reactions proceeded smoothly and afforded its desired products in excellent yields. Among these analogues, 3y exhibited a better cytotoxic effect on human hepatocellular carcinoma (HCC) Hep 3B cells and displayed less cytotoxicity on normal human umbilical vein endothelial cells, compared with Sorafenib, a targeted therapy for advanced HCC. 3y also induced stronger apoptosis and autophagy. Addition of curcumin enhanced 3y-induced cytotoxicity by further induction of autophagy. Using gene expression signatures of 3y to query Connectivity Map, a glycogen synthase kinase-3 inhibitor (AR-A014418) was predicted to display similar molecular action of 3y. Experiments further demonstrate that AR-A014418 acted like 3y, and vice versa. Overall, our data suggest the chemotherapeutic potential of 3y on HCC.

A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.