315703-52-7

Basic information

• Product Name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
• Synonyms: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine;JK 184;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-;Hh Signaling Antagonist VII, JK184
• CAS NO: 315703-52-7
• Molecular Formula: C19H18N4OS
• Molecular Weight: 350.444
• Mol File: 315703-52-7.mol
• Article Data: 3

Chemical Properties

• Appearance: off-white to light brown/
• Density: 1.3
• Storage Temp.: Store at +4°C
• Solubility: DMSO: ≥20mg/mL
• Water Solubility: soluble to 100 mM in DMSO and to 25 mM in ethanol
• CAS DataBase Reference: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine(315703-52-7)
• EPA Substance Registry System: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine(315703-52-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 315703-52-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 315703-52-7 differently. You can refer to the following data:
1. JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
2. JK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.

Biological Activity

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .

Upstream product

• 1159606-89-9 2-chloro-1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone 
• 880-29-5 1-(4-ethoxyphenyl)thiourea 
• 934-37-2 2-methylimidazo[1,2-a]pyridine 
• 2565-30-2 formyl chloride 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

The imidazopyridine derivative JK184 reveals dual roles for microtubules in hedgehog signaling

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COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-fu