5348-26-5

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 95-55-6 2-amino-phenol 

Downstream Products

• 840-56-2 2-(3-nitrophenyl)benzoxazole 
• 41373-36-8 2-(3-hydroxyphenyl)benzothiazole 
• 1101875-67-5 [Cu(3-nitrobenzylidene-2-aminophenolate)(1,10-phenanthroline)Cl(H₂O)] 
• 1044591-69-6 4-(3'-nitrophenyl)-4-(N-2'-hydroxy-phenyl)aminobut-1-ene 
• 1361930-96-2 Ru(NO₂(C₆H₃)CHN(C₆H₄)O)(P(C₆H₅)3)2Cl 
• 1610857-90-3 C₂₉H₂₄CuN₅O₅⁽¹⁺⁾*Cl^(1-) 
• 1610857-91-4 C₂₉H₂₄N₅O₅Zn⁽¹⁺⁾*Cl^(1-) 
• 1610857-92-5 C₂₉H₂₄Cl₂FeN₅O₅ 
• 1610857-88-9 C₂₉H₂₄CoN₅O₅⁽¹⁺⁾*Cl^(1-) 
• 1610857-89-0 C₂₉H₂₄N₅NiO₅⁽¹⁺⁾*Cl^(1-) 
• 3164-06-5 2-(3-hydroxyphenyl)-1,3-benzoxazole 

Relevant academic research and scientific papers

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

Catalyst-free allylation of 2-aminophenol–derived aldimines with allyltrichlorosilane under thermal conditions

Allylation of 2-aminophenol-derived aldimines using allyltrichlorosilane under catalyst free conditions has been developed. This reaction afforded the corresponding homoallylic amines in good to excellent yields (68–94%). The salicylaldehyde-derived aldimines as well as benzoylhydrazone also found to react with allyltrichlorosilane smoothly under the same conditions, to furnish the corresponding homoallylic amine derivatives. This study suggests that the phenolic –OH group acts as an anchoring group for the transfer of allyl group from allyl silane reagent.

Synthesis and biological activities of 2-aminophenol-based Schiff bases and their structure-activity relationship

Six Schiff bases 8-13 were synthesized by condensation of 2-aminophenol (1) with various chloro- and nitro-benzaldehydes (2-7), characterized, and evaluated for antioxidant, antibacterial, lipoxygenase, and urease inhibitory potentials. All Schiff bases e

Metal-based molecular design tuning biochemical behavior: Synthesis, characterization, and biochemical studies of mixed ligand complexes derived from 4-aminoantipyrine derivatives

Biosensitive mixed ligand complexes of metals (Fe(III), Co(II), Ni(II), Cu(II), and Zn(II)) with the Schiff bases of L1 and HL2 (L1: obtained through the condensation of 4-aminoantipyrine with furfuraldehyde; HL2/sup