5348-26-5

Basic information

• Product Name: 2-{[(E)-(3-nitrophenyl)methylidene]amino}phenol
• Synonyms: 2-{[(E)-(3-Nitrophenyl)methylene]amino}phenol; phenol, 2-[[(1E)-(3-nitrophenyl)methylene]amino]-
• CAS NO: 5348-26-5
• Molecular Formula: C₁₃H₁₀N₂O₃
• Molecular Weight: 242.2301
• Mol File: 5348-26-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 448.6°C at 760 mmHg
• Flash Point: 225.1°C
• Density: 1.25g/cm³
• Vapor Pressure: 1.16E-08mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 2-{[(E)-(3-nitrophenyl)methylidene]amino}phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(E)-(3-nitrophenyl)methylidene]amino}phenol(5348-26-5)
• EPA Substance Registry System: 2-{[(E)-(3-nitrophenyl)methylidene]amino}phenol(5348-26-5)

Safety Data

• Hazardous Substances Data: 5348-26-5(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 95-55-6 2-amino-phenol 

Downstream Products

• 1361930-96-2 Ru(NO₂(C₆H₃)CHN(C₆H₄)O)(P(C₆H₅)3)2Cl 
• 3164-06-5 2-(3-hydroxyphenyl)-1,3-benzoxazole 
• 1044591-69-6 4-(3'-nitrophenyl)-4-(N-2'-hydroxy-phenyl)aminobut-1-ene 
• 1610857-89-0 C₂₉H₂₄N₅NiO₅⁽¹⁺⁾*Cl^(1-) 
• 1610857-88-9 C₂₉H₂₄CoN₅O₅⁽¹⁺⁾*Cl^(1-) 
• 1610857-92-5 C₂₉H₂₄Cl₂FeN₅O₅ 
• 1610857-91-4 C₂₉H₂₄N₅O₅Zn⁽¹⁺⁾*Cl^(1-) 
• 1610857-90-3 C₂₉H₂₄CuN₅O₅⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

Synthesis and biological activities of 2-aminophenol-based Schiff bases and their structure-activity relationship

Six Schiff bases 8-13 were synthesized by condensation of 2-aminophenol (1) with various chloro- and nitro-benzaldehydes (2-7), characterized, and evaluated for antioxidant, antibacterial, lipoxygenase, and urease inhibitory potentials. All Schiff bases e

OXIDATION WITH NICKEL PEROXIDE. IV. THE PREPARATION OF BENZOXAZOLES

-