317339-82-5

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 317339-72-3 4-(phenylsulfonyl)-1-tosyl-5,6-dihydro-2-pyridone 
• 317339-60-9 4-phenylsulfanyl-1-(toluene-4-sulfonyl)-5,6-dihydro-1H-pyridin-2-one 
• 4083-64-1 Tosyl isocyanate 

Relevant academic research and scientific papers

Synthesis and applications of tetrahydro-2-pyridinones via aza-Diels - Alder reactions of thio-substituted 1,3-dienes with arylsulfonyl isocyanates

The first aza-Diels - Alder reactions of arylsulfonyl isocyanates with thio-substituted 1,3-dienes via the 3-sulfolene precursors 1 gave the cyclized products 3 with complete control of chemo- and regioselectivity. The cyclized products 3a and 5 underwent further reactions with nucleophiles and bases to give useful heterocyclic compounds. The N-tosyl group of the cyclic products could be selectively replaced by hydrogen or another substituent.

Aza-Diels-Alder reactions and synthetic applications of thio-substituted 1,3-dienes with arylsulfonyl isocyanates

The first aza-Diels-Alder reactions of arylsulfonyl isocyanates with thio-substituted 1,3-dienes via the 3-sulfolene precursors 1 gave the cyclized products 3 with complete control of regio- and chemoselectivity. The cyclized products 3a and 4 underwent further interesting reactions with nucleophiles and bases to give useful heterocyclic compounds. (C) 2000 Elsevier Science Ltd.