31788-39-3Relevant academic research and scientific papers
Concise and Convergent Enantioselective Total Syntheses of (+)-and (-)-Fumimycin
Retini, Michele,Bartolucci, Silvia,Bartoccini, Francesca,Mari, Michele,Piersanti, Giovanni
, p. 12221 - 12227 (2019/10/02)
The concise and convergent total syntheses of (+)-and (-)-Fumimycin have been achieved by taking advantage of strategies for the asymmetric aza-Friedel-Crafts reaction of a highly substituted hydroquinone and N-fumaryl ketimine generated from the correspo
Synthesis of methoxyfumimycin with 1,2-addition to ketimines
Gross, Patrick J.,Hartmann, Caroline E.,Nieger, Martin,Braese, Stefan
scheme or table, p. 229 - 232 (2010/04/24)
(Chemical Equation Presented) The synthesis of (±)-methoxyfumimycin, a potential new bacterial peptide deformylase (PDF) inhibitor, is reported. To generate the stereogenic fully substituted carbon, the key step is a 1,2-addition of amethylGrignard reagent to a ketimine. The overall synthetic strategy involves a Dakin oxidation of a vanillin derivative, Friedel-Crafts acylation, Claisen rearrangement, lactonization, and rhodium-catalyzed olefin isomerization.
Bi(OTf)3-catalyzed allylation of quinones with allyltrimethylsilane
Yadav,Reddy,Swamy
, p. 4861 - 4864 (2007/10/03)
p-Quinones react smoothly with allyltrimethylsilane in the presence of 2 mol% of Bi(OTf)3 under mild reaction conditions to afford the corresponding allyl substituted benzene derivatives, p-allylquinols and allyl substituted 1,4-naphthoquinones in excellent yields with high regioselectivity. This method is very useful for the direct introduction of an allyl functionality onto a quinone moiety.
Feeding-deterrent activity of α-asarone isomers against some stored Coleoptera
Poplewski, Janusz,Lozowicka, Bozena,Dubis, Alina T.,Lachowska, Barbara,Winiecki, Zbigiew,Nawrot, Jan
, p. 560 - 564 (2007/10/03)
All isomers of α-asarone [(E)-4-prop-1-enyl-1,2,5-trimethoxybenzene] were tested for their feeding deterrent activity against adults of Sitophilus granarius and Tribolium confusum and larvae of Trogoderma granarium and Tribolium confusum. (E)-2-prop-1-eny
Synthesis and hypolipidemic and antiplatelet activities of α-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo)
Poplawski,Lozowicka,Dubis,Lachowska,Witkowski,Siluk,Petrusewicz,Kaliszan,Cybulski,Strzalkowska,Chilmonczyk
, p. 3671 - 3676 (2007/10/03)
A series of α-asarone isomers was synthesized and investigated for their hypolipidemic and antiplatelet activity. Considering the hypolipidemic activity in rats at a dose of 80 mg/kg/day, some isomers were more potent than clofibrate at 150 mg/kg. Compoun
Crystal structures of 1,2,5-trimethoxy-3-(1-propenyl)benzene and 1,3,5-trimethoxy-2-(1-propenyl)benzene
Wolska,Poplawski,Lozowicka
, p. 2331 - 2341 (2007/10/03)
The crystal structures of 1,2,5-trimethoxy-3-(1-propenyl)benzene (D) and 1,3,5-trimethoxy-2-(1-propenyl)benzene (F) have been determined by X-ray diffraction methods. The compounds crystallize in the monoclinic system, space group P21/c for (D)
