5273-82-5Relevant academic research and scientific papers
Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives
Zhang, Jian,Mu, Keman,Yang, Peng,Feng, Xinqian,Zhang, Di,Fan, Xiangyu,Wang, Qiantao,Mao, Shengjun
, (2021/08/03)
In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.
Role of the methoxy group in product formation via TiCl 4 promoted 4-phenyldioxolane isomerizations
Green, Ivan R.,October, Natasha
experimental part, p. 71 - 96 (2010/07/20)
The product distribution obtained from the TiCl 4 initiated intramolecular isomerizations of 4-methoxyphenyl-and trimethoxyphenyldioxolanes at -78 °C, -30 °C and 0 °C provided insights into the important regiochemical role played by these groups in such Mukaiyama-type rearrangements through their resonance effects on the aryl ring of the dioxolanes. ARKAT USA, Inc.
Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin
Hartmann, Caroline E.,Gross, Patrick J.,Nieger, Martin,Braese, Stefan
supporting information; experimental part, p. 5059 - 5062 (2010/04/04)
Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the α,α-disubstituted amino acid unit and results in the synthesis of an advanced inter
Synthesis and hypolipidemic and antiplatelet activities of α-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo)
Poplawski,Lozowicka,Dubis,Lachowska,Witkowski,Siluk,Petrusewicz,Kaliszan,Cybulski,Strzalkowska,Chilmonczyk
, p. 3671 - 3676 (2007/10/03)
A series of α-asarone isomers was synthesized and investigated for their hypolipidemic and antiplatelet activity. Considering the hypolipidemic activity in rats at a dose of 80 mg/kg/day, some isomers were more potent than clofibrate at 150 mg/kg. Compoun
Feeding-deterrent activity of α-asarone isomers against some stored Coleoptera
Poplewski, Janusz,Lozowicka, Bozena,Dubis, Alina T.,Lachowska, Barbara,Winiecki, Zbigiew,Nawrot, Jan
, p. 560 - 564 (2007/10/03)
All isomers of α-asarone [(E)-4-prop-1-enyl-1,2,5-trimethoxybenzene] were tested for their feeding deterrent activity against adults of Sitophilus granarius and Tribolium confusum and larvae of Trogoderma granarium and Tribolium confusum. (E)-2-prop-1-eny
Crystal structures of 1,2,5-trimethoxy-3-(1-propenyl)benzene and 1,3,5-trimethoxy-2-(1-propenyl)benzene
Wolska,Poplawski,Lozowicka
, p. 2331 - 2341 (2007/10/03)
The crystal structures of 1,2,5-trimethoxy-3-(1-propenyl)benzene (D) and 1,3,5-trimethoxy-2-(1-propenyl)benzene (F) have been determined by X-ray diffraction methods. The compounds crystallize in the monoclinic system, space group P21/c for (D)
Synthesis of 2,3,5-Trihyroxyphenylprop-1-ene and its 4-Chloro-, 6-Chloro-, and 4,6-Dichloro- Derivatives
Hill, Robert A.,Macaulay, Graham S.,MacLachlan, William S.
, p. 2209 - 2216 (2007/10/02)
The synthesis of (E)-2,3,5-trihydroxyphenylprop-1-ene (2) and its 4-chloro- (3), 6-chloro- (4), and 4,6-dichloro- derivatives (5) is described.The routes involve the key intermediates, methyl 2,3,5-tribenzyloxybenzoate (15) and methyl 2,3,5-tribenzyloxy-4
