31848-98-3

Upstream product

• 1575-61-7 5-Chlorovaleroyl chloride 
• 927-73-1 3-butenyl chloride 
• 100-52-7 benzaldehyde 
• 139527-25-6 bis(4-chlorobutyl)zinc 
• 100-58-3 phenylmagnesium bromide 
• 71-43-2 benzene 
• 1195776-84-1 1-methoxymethoxy-1-phenyl-5-chloropentane 
• 501-53-1 benzyl chloroformate 
• 22815-63-0 N-^t-butyl benzylcarbamate 
• 6940-78-9 4-chlorobutyl bromide 
• 20074-80-0 5-chloro-pentanal 
• 942-93-8 5-Chloro-1-phenyl-1-pentanone 

Downstream Products

• 4203-44-5 2-phenyltetrahydropyran 
• 123537-30-4 (S)-2-phenyltetrahydro-2H-pyran 
• 1554032-30-2 methyl 4-benzoyl-3-(4-methylphenyl)-4-pentenoate 
• 202325-96-0 1,5-dichloro-1-phenylpentane 
• 66534-77-8 3-phenyl-2,2-dimethylheptan-3-ol 
• 66860-64-8 5-iodo-1-phenyl-1-pentanone 
• 1009-14-9 phenyl butyl ketone 
• 10487-96-4 1-phenylcyclopentanol 
• 65002-76-8 N-(5-Dimethylamino-1-phenyl-pentyl)-benzamide 
• 1622-06-6 2-phenyl-tetrahydro-thiopyran 
• 176503-81-4 N-(5-Chloro-1-phenyl-pentyl)-benzamide 
• 942-93-8 5-Chloro-1-phenyl-1-pentanone 

Relevant academic research and scientific papers

Chemoselective lithiation of 1-Bromo-n-chloroalkanes

Reactions between different 1-bromo-n-chloroalkanes (1-3), lithium/naphthalene (1:2 molar ratio) and a carbonyl compound R 1R2CO in THF at -78°C provide, after hydrolysis with water, the corresponding chlorinated alcohols 4 through s

Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

A series of bifunctional phosphine oxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asymmetric hydrosilylation of ketimines. bis-Phosphine oxides, hydroxy-phosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide displayed the highest enantioselectivity of 60%.

Effect of functional groups in organic chlorides on radical reduction with hydrostannane under microwave irradiation

The effect of functional groups on the activation of molecules by microwave irradiation in the reduction of organic chlorides by Bu3SnH was investigated. The reactivity of a substrate with a hydroxy group increased under microwave heating conditions in comparison with conventional heating.

A combined computational and experimental investigation of the oxidative ring-opening of cyclic ethers by oxoammonium cations

The propensity of oxoammonium cations to facilitate the oxidative ring-opening of cyclic ethers to their corresponding distal hydroxy ketones is investigated. The reaction has been evaluated using experimental and computational methods to gain deeper insight into trends in reactivity.

Direct metalation of methoxymethyl arylmethyl ethers: A tin-free approach to the generation of α-alkoxyalkoxy-substituted aryllithiums

The generation of a series of α-methoxymethoxy-substituted arylmethyllithiums was achieved by direct metalation of the corresponding arylmethyl methoxymethyl ethers. While the effect of substituents at the benzylic position is straightforward, substituent

Reductive opening of phenyl substituted thiacycloalkanes: New way for sulphur-containing organolithium compounds

The reaction of 2-phenyl substituted four, five and six membered thiacycloalkanes (1, 4 and 7) with lithium and a catalytic amount of DTBB (5 mol %) in THF at -78°C leads to the corresponding sulphur-containing benzylic organolithium compounds (2, 5 and 8), which by reaction with different electrophiles [D2O, Me3SiCl, Bu(t)CHO, Me2CO, Et2CO, (CH2)4CO, CO2] followed by hydrolysis with water afford the expected functionalised mercaptans (3, 6 and 9) in a regioselective manner. Some reaction products (3, 6) are cyclised under acidic conditions (85% phosphoric acid) to yield the corresponding homologous substituted sulphur-containing saturated heterocycles (10, 11).

New Route to N-(Dialkylaminoalkyl)benzamides

A new method is developed for preparing N-(dialkylaminoalkyl)benzamides with a secondary or tertiary carbon atom at the amide nitrogen atom by condensation of chloro alcohols with nitriles in strongly acidic media, followed by amination of the resulting c

Preparation of Functionalized Dialkylzinc Reagents via an Iodine-Zinc Exchange Reaction. Highly Enantioselective Synthesis of Functionalized Secondary Alcohols

Functionalized dialkylzincs are obtained by the reaction of polyfunctional alkyl iodides with Et2Zn in excellent yield.Their treatment with aldehydes, in the presence of the titanium catalyst 6, affords functionalized secondary alcohols with high enantios

CARBAMATE DIANIONS: GENERATION AND ALKYLATION OF α-OXO CARBANIONS

Dianions from simple N-t-butyl benzylic-type carbamates are readily formed with alkyllithium bases and undergo alkylation with a variety of electrophiles.Both secondary and tertiary α-oxo carbanions are easily accessible.DIBAL cleavage of the c