31883-79-1

Basic information

• Product Name: 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
• Synonyms: 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;3-METHYL-3,4-DIHYDROQUINOLIN-2(1H)-ONE
• CAS NO: 31883-79-1
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 31883-79-1.mol
• Article Data: 21

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 325.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.083±0.06 g/cm3(Predicted)
• PKA: 14.80±0.40(Predicted)
• CAS DataBase Reference: 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(31883-79-1)
• EPA Substance Registry System: 3-METHYL-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(31883-79-1)

Safety Data

• Hazardous Substances Data: 31883-79-1(Hazardous Substances Data)

Upstream product

• 5570-18-3 2-aminophenylboronic acid 
• 80-62-6 methacrylic acid methyl ester 
• 191171-55-8 2-anilineboronic acid pinacol ester 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 10113-38-9 N-(2-bromophenyl)formamide 
• 1536478-59-7 (E)-N-[2-(prop-1-enyl)phenyl]formamide 
• 1536478-63-3 (Z)-N-[2-(prop-1-enyl)phenyl]formamide 
• 32704-22-6 2-allyl-phenylamine 
• 589-09-3 N-allyl-N-phenylamine 
• 17496-14-9 2,3-dihydro-2-methyl-1H-inden-1-one 
• 792122-85-1 1-[(4-methoxyphenyl)methyl]-3-methyl-3,4-dihydroquinolin-2-one 
• 792122-84-0 1-[(4-methoxyphenyl)methyl]-3,4-dihydroquinolin-2-one 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 1611-83-2 2-methyl-N-phenylacrylamide 

Downstream Products

• 2721-59-7 3-methylcarbostyril 
• 113092-96-9 6-bromo-2-chloro-3-methylquinoline 
• 57876-69-4 2-chloro-3-methyl-quinoline 
• 113093-17-7 3-Chloro-3-methyl-3,4-dihydro-1H-quinolin-2-one 
• 92367-59-4 3,3-dimethyl-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

Evaluating thiourea/urea catalyst for enantioselective 6π-photocyclization of acrylanilides

6π-Photocyclization of acrylanilide with thiourea and urea based organocatalysts were evaluated to develop H-bonding activated photochemical reactions. These photochemical reactions resulted in a 3,4-dihydroquinolin-2-one photoproduct with low enantioselectivity. Photophysical studies revealed catalyst-substrate interactions in the excited state. The low chiral induction is likely due to a combination of low stereodifferentiation with respect to the mode of cyclization of the substrate by the catalyst, formation of an enol intermediate that destroys the chirality and the relative reactivity of the zwitterionic intermediate that competes with enol formation and direct hydrogen atom migration.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Provided herein are novel heterocyclic compounds, for example, compounds having Formula I, I-P, II, lI-P, or III. Also provided herein are pharmaceutical compositions comprising the compounds and methods of using the same, for example, in inhibiting aldehyde dehydrogenases and/or for treating various cancers, cancer metastasis, type 2 diabetes, pulmonary arterial hypertension (PAH) or neointimal hyperplasia (NIH).

Regiodivergent access to five- and six-membered benzo-fused lactams: Ru-catalyzed olefin hydrocarbamoylation

We report herein a new strategy of the Ru-catalyzed intramolecular olefin hydrocarbamoylation for the regiodivergent synthesis of five- and six-membered benzo-fused lactams starting from N-(2-alkenylphenyl)formamides. Using a combined catalyst of Ru3