31949-41-4Relevant academic research and scientific papers
Synthesis of anabaseine and anabasine derivatives: Structural modifications of possible nicotinic agonists
Sobarzo-Sanchez, Eduardo,Castedo, Luis,De La Fuente, Julio R.
, p. 1331 - 1338 (2007)
Coupling nicotinoyl chloride with 3,4-dimetoxyphenethylamine under Bischler-Napieralski cyclization afforded the isoquinoline (4) in good yield. This latter was used as starting material to obtain with only hydrobromic acid a product with demethylation at
Complete assignments 1H and13C NMR spectral data of four anabaseine derivatives
Sobarzo-Sanchez, Eduardo,De La Fuente, Julio,Quezada, Elias,Castedo, Luis
, p. 1131 - 1134 (2008/02/03)
The anabaseine derivatives 6-methoxy-7-hydroxy-1-(pyridin-3-yl)-3,4- dihydroisoquinoline, 6,7-dimethoxy-1-(pyridin-3-yl)-1,2,3,4- tetrahydroisoqumoline and 6,7-dimethoxy-1-(piperidin-3-yl)-1,2,3,4- tetrahydroisoquinoline were prepared either by demethylation with HBr or by reduction with different reagents, NaBH4 and H2/PtO 2 from 6,7-dimethoxy-1-(pyridin-3-yl)-3,4-dihydroisoquinoline, as starting material. The structures have been fully assigned by the combination of one- and two-dimensional experiments. Copyright
Diazaestrones and analogs. II. Structural modifications of succinimidoethyldihydroisoquinoline, heterosteroid precursor, to establish structure-analgesic activity relationship
Hocquaux,Viel,Brunaud,et al.
, p. 331 - 338 (2007/10/02)
β-1-(succinimidoethyl)-6,7-dimethoxydihydroisoquinoline having exihibited a stronger analgesic activity than the methylester of 2-methoxy-8,13-diazaestrone, its structure has been systematically modified in view of establishing a relation between structur
