32001-59-5

Upstream product

• 122-59-8 2-phenoxyacetic acid 
• 71-36-3 butan-1-ol 
• 7397-62-8 butyl glycolate 
• 108-95-2 phenol 
• 590-02-3 butyl chloroacetate 
• 112445-76-8 4-methoxyphenyl 2-phenoxyacetate 
• 19513-78-1 1-(4-methoxy-phenyl)-2-phenoxy-ethanone 
• 621-88-5 phenoxyacetamide 
• 109-65-9 1-bromo-butane 
• 3598-16-1 2-phenoxyacetic acid sodium salt 

Downstream Products

• 94-80-4 Fernesta 
• 3035-67-4 2,4-dichlorophenoxyacetic acid isooctyl ester 
• 52716-17-3 n-butyl 4-chlorophenoxyacetate 

Relevant academic research and scientific papers

KPF6-Mediated Esterification and Amidation of Carboxylic Acids

A novel KPF6-promoted green method has been developed for the synthesis of esters and amides. A wide range of carboxylic acids and alcohols or amines worked well under the developed reaction conditions, thus providing good to excellent (61-98%) yields of

Preparation method of 2,4-dichlorophenoxyacetic acid and salt thereof

The invention provides a preparation method of 2,4-dichlorophenoxyacetic acid and a salt thereof, wherein the preparation method includes the following steps: S1) carrying out a reaction of phenol andchloracetic ester under alkaline conditions to obtain phenoxyacetic ester; S2) carrying out selective chlorination reaction of the phenoxyacetic ester with a chlorinating agent under the action of acatalyst A and a catalyst B to obtain 2,4-dichlorophenoxyacetic ester, wherein the catalyst A is Lewis acid, and the catalyst B is C5-22 thioethers, thiazoles, isothiazoles and thiophenes or halogenated derivatives thereof; and S3) carrying out hydrolysis reaction of 2,4-dichlorophenoxyacetic ester under acidic conditions to obtain 2,4-dichlorophenoxyacetic acid; or after 2,4-dichlorophenoxyaceticester is obtained, carrying out an alkaline hydrolysis reaction with an alkaline compound to obtain 2,4-dichlorophenoxyacetate. The production and use of 2,4-dichlorophenol with unpleasant odor are avoided, the production of dioxins is eliminated, the yield of products is improved, and the output of three wastes is greatly reduced.

Preparation method of phenoxycarboxylic acid choline salt

The invention provides a preparation method of a phenoxycarboxylic acid choline salt, wherein the preparation method includes the steps: S1, carrying out condensation reaction of phenol or o-cresol with chlorocarboxylic ester in the presence of alkaline substances to obtain phenoxycarboxylic ester; S2, carrying out selective chlorination of the phenoxycarboxylic ester with a chlorinating agent inthe presence of a first catalyst and a second catalyst to obtain chlorobenzoxycarboxylic ester; and S3, after reaction of trimethylamine with ethylene oxide, adding the chlorophenoxycarboxylic acid ester, and carrying out alkaline hydrolysis reaction to obtain the phenoxycarboxylic acid choline salt. Compared with a conventional synthesis technology, the preparation method effectively avoids the production and use of chlorophenols with unpleasant odor, radically eliminates the production of highly toxic dioxins, and greatly improves the product quality and the operation environment of the production site; with phenol as the raw material, through condensation, selective chlorination and alkaline hydrolysis, the high-quality phenoxycarboxylic acid choline salt is obtained, the loss of effective ingredients is effectively avoided and the yield of the product is increased.

A phenoxy carboxylic acid ester herbicide preparation method (by machine translation)

The invention provides a phenoxy carboxylic acid ester herbicide preparation method, including: S1, phenol in the presence of alkaline substance with the chlorinated carboxylic acid ester condensation reaction, phenoxy carboxylic acid ester obtained; the ClR states the chloro- carboxylic acid ester of the general formula1 COOR, R1 Is C1 - 3 alkylene or alkylidene, R is C1 - 10 alkyl or C3 - 10 cycloalkyl; S2, the [...] ester in the 1st and 2nd catalyst the presence of a catalyst, with the chlorinating agent to carry out the selective chlorination of, get [...] ester; the Lewis acid catalyst is selected from the 1st, the 2nd catalyst is C5 - 22 of the thioether, thiazole, thiophene compounds or different benzisothiazoles; S3, will the [...] ester with an alcohol reaction, as shown in formula I phenoxy carboxylic acid ester herbicide; R3 Is H, Cl or CH3 , R ' is a C4 - 20 alkyl or cycloalkyl. This invention can improve the product quality and the production environment, three waste low. (by machine translation)

Preparation method of phenoxycarboxylic ester

The invention provides a preparation method of phenoxycarboxylic ester, comprising the following step: a phenolic compound and hydroxycarboxylic ester react under the action of a catalyst to obtain phenoxycarboxylic ester, wherein the catalyst is one or more of protonic acid, solid acid and a supported catalyst. By using the phenolic compound and hydroxycarboxylic ester as the raw materials, the reaction is carried out in a chloride-free nonmetallic ion system, and generation of high salinity wastewater and metal chloride by-product is completely eradicated. Therefore, washing brine is saved,and wastewater quantity is greatly reduced. The wastewater quantity is reduced from original at least 25 tons to 82 kg for one ton of the product. According to the invention, the technological processis simplified, loss of active ingredients is reduced, yield of active ingredients is increased, and product purity is high. Meanwhile, the method is convenient for continuous production, production period is short, and raw materials are easily available. Therefore, the production cost is reduced.

Highly effective C-C bond cleavage of lignin model compounds

A highly effective method is developed for the C-C bond cleavage of lignin model compounds. The inert Cα-Cβ or Cα-Cphenyl bond of oxidized lignin model compounds was successfully converted to an active ester bond through the classic organic name reaction, Baeyer-Villiger (BV) oxidation, and thus acetal esters and aryl esters were produced in high yields (up to 99%) at room temperature. Next, K2CO3 catalyzed the alcoholysis of the resulting ester products at 45 °C, affording various useful chemical platforms in excellent yields (up to 99%), such as phenols and multifunctional esters. This method uses commercially available reagents, is transition-metal free and simple, but highly effective, and involves mild reaction conditions.

Mild conversion of primary carboxamides into carboxylic esters

Primary carboxamides are converted into the corresponding alkyl carboxylates by treatment with dimethylformamide dimethylacetal in the appropriate alcohol at 25-45°C. Yields are very good to excellent.

Electrochemical generation and reactions of acyloxytriphenylphosphonium ions

Constant-current electrolysis, in an undivided cell, of Ph3P in the presence of a carboxylic acid in CH2Cl2 containing 2,6-lutidinium perchlorate as the supporting electrolyte was shown to generate the corresponding acyloxyphosphonium ion, Ph3P+-OCOR, which was converted in situ to esters, amides, and β-lactams under mild conditions.

Use of Anion Exchange Resin in Synthesis of Aryloxyacetic Acid Esters

Insoluble polymer-supported nucleophilic reagent has been prepared by treatment of sodium salt of aryloxyacetic acid with Amberlite IRA-400 (Cl-).This reagent has been used for the synthesis of aryloxyacetic acid esters in high yields by reaction with alkyl halides.In addition to ease and simplicity of the method and regeneration of the polymeric by-product, the polymeric reagent seems to increase the nucleophilicity of the anions.In addition to this, transesterification is observed when alcohol is used as the solvent.