94-80-4Relevant articles and documents
Synthesis method of substituted phenoxyacetate compound
-
Paragraph 0062; 0063; 0064, (2019/08/01)
The invention discloses a synthesis method of a substituted phenoxyacetate compound, relates to a synthesis method of a compound and aims to solve the problems that during current preparation of the substituted phenoxyacetate compound by a condensation method, a large amount of organic agent is consumed, substituted phenol is unlikely to react completely, the content of free phenol in three wastesis high and a very high environmental risk exists. According to the synthesis method, after the substituted phenol is mixed with haloacetate, a condensation reaction is performed in a potassium fluoride system condensing agent under the synergistic catalysis of a phase transfer catalyst and a halogenated hydrocarbon activator to obtain a substituted phenoxyacetic acid compound. The synthesis method is applied to the field of compound synthesis.
Preparation method of 2,4-dichlorophenoxyacetic acid and salt thereof
-
, (2019/01/06)
The invention provides a preparation method of 2,4-dichlorophenoxyacetic acid and a salt thereof, wherein the preparation method includes the following steps: S1) carrying out a reaction of phenol andchloracetic ester under alkaline conditions to obtain phenoxyacetic ester; S2) carrying out selective chlorination reaction of the phenoxyacetic ester with a chlorinating agent under the action of acatalyst A and a catalyst B to obtain 2,4-dichlorophenoxyacetic ester, wherein the catalyst A is Lewis acid, and the catalyst B is C5-22 thioethers, thiazoles, isothiazoles and thiophenes or halogenated derivatives thereof; and S3) carrying out hydrolysis reaction of 2,4-dichlorophenoxyacetic ester under acidic conditions to obtain 2,4-dichlorophenoxyacetic acid; or after 2,4-dichlorophenoxyaceticester is obtained, carrying out an alkaline hydrolysis reaction with an alkaline compound to obtain 2,4-dichlorophenoxyacetate. The production and use of 2,4-dichlorophenol with unpleasant odor are avoided, the production of dioxins is eliminated, the yield of products is improved, and the output of three wastes is greatly reduced.
Preparation method and application of composition of 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetate
-
Paragraph 0102; 0103, (2018/09/08)
The invention provides a preparation method for a composition of 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetate. The preparation method comprises the following steps: reacting halogenated acetate with 2,4-dichlorophenate so as to obtain 2,4-dichlorophenoxyacetate; and directionally hydrolyzing 2,4-dichlorophenoxyacetate prepared in the previous step to obtain the composition of 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetate. According to the invention, a process route is adjusted and creative improvement is made from the foundation; halogenated acetate reacts with2,4-dichlorophenate so as to prepare 2,4-dichlorophenoxyacetate, and directional hydrolysis is carried out so as to obtain the composition of 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetate. The composition of 2,4-dichlorophenoxyacetic acid and 2,4-dichlorophenoxyacetate of the invention has excellent quality, high stability and good drug effect.