3202-33-3

Basic information

• Product Name: 4-PHENOXYPIPERIDINE
• Synonyms: 4-PHENOXYPIPERIDINE;4-Phenoxy-piperidine 1HCl salt
• CAS NO: 3202-33-3
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Product Categories: Amines;blocks
• Mol File: 3202-33-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 107-108°C/0.1mm
• Flash Point: 107-108°C/0.1mm
• Appearance: /
• Density: 1.03 g/cm³
• Vapor Pressure: 0.0043mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.62±0.10(Predicted)
• CAS DataBase Reference: 4-PHENOXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENOXYPIPERIDINE(3202-33-3)
• EPA Substance Registry System: 4-PHENOXYPIPERIDINE(3202-33-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 3202-33-3(Hazardous Substances Data)

Usage

General Description

4-Phenoxy piperidine is a chemical compound with the molecular formula C11H15NO. It is a piperidine derivative that contains a phenoxy group, which is a benzene ring attached to an oxygen atom. This chemical is used in the synthesis of pharmaceuticals and agrochemicals due to its unique structural properties. 4-Phenoxy piperidine is known to have psychoactive effects and may act as a dopamine receptor agonist. It is an important intermediate in the preparation of various medications and is also used as a building block in the production of bioactive molecules. Additionally, it has been studied for its potential insecticidal and acaricidal properties.

InChI:InChI=1/C11H15NO/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-5,11-12H,6-9H2

Upstream product

• 155989-69-8 tert-butyl 4-phenoxypiperidine-1-carboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 4783-86-2 4-phenoxypyridine 
• 100-39-0 benzyl bromide 
• 3112-85-4 methylphenylsulfonate 

Downstream Products

• 639855-29-1 C₁₈H₂₂ClN₅O₂ 
• 180157-22-6 (2S)-(-)-1-(4-indolyloxy)-3-(4-phenoxypiperidin-1-yl)-2-propanol ethanedioate 
• 1025887-31-3 4-phenoxy-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-piperidine 
• 855267-34-4 3-(4-phenoxypiperidin-1-yl)propan-1-ol 

Relevant articles and documents

Radical Anion Promoted Chemoselective Cleavage of Csp2-S Bond Enables Formal Cross-Coupling of Aryl Methyl Sulfones with Alcohols

A novel formal cross-coupling of aryl methyl sulfones and alcohols affording alkyl aryl ethers via an SRN1 pathway is developed. Two marketed antitubercular drugs were efficiently prepared employing this approach as the key step. A dimsyl-anion initiated radical chain process was revealed as the major pathway. DFT calculations indicate that the formation of a radical anion via nucleophilic addition of alkoxide to the aryl radical is the key step in determining the observed chemoselectivity.

Synthesis of 11C-labelled ureas by palladium(II)-mediated oxidative carbonylation

Positron emission tomography is an imaging technique with applications in clinical settings as well as in basic research for the study of biological processes. A PET tracer, a biologically active molecule where a positron-emitting radioisotope such as carbon-11 has been incorporated, is used for the studies. Development of robust methods for incorporation of the radioisotope is therefore of the utmost importance. The urea functional group is present in many biologically active compounds and is thus an attractive target for incorporation of carbon-11 in the form of [11C]carbon monoxide. Starting with amines and [11C]carbon monoxide, both symmetrical and unsymmetrical 11C-labelled ureas were synthesised via a palladium(II)-mediated oxidative carbonylation and obtained in decay-corrected radiochemical yields up to 65%. The added advantage of using [11C]carbon monoxide was shown by the molar activity obtained for an inhibitor of soluble epoxide hydrolase (247 GBq/μmol-319 GBq/μ mol). DFT calculations were found to support a reaction mechanism proceeding through an 11C-labelled isocyanate intermediate.

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.