3202-33-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Phenoxypiperidine is used as a key intermediate in the synthesis of various medications due to its unique structural properties and potential psychoactive effects. It plays a significant role in the development of new pharmaceutical compounds, particularly those targeting the dopamine receptor.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Phenoxypiperidine is utilized as a building block in the production of bioactive molecules, contributing to the development of effective pesticides and other agrochemicals.
Used in Chemical Research:
4-Phenoxypiperidine is employed as a research compound in the study of its psychoactive effects and potential as a dopamine receptor agonist, aiding in the understanding of its mechanisms of action and potential therapeutic applications.
Used in Insecticidal and Acaricidal Applications:
4-Phenoxypiperidine is used as an active ingredient in the development of insecticides and acaricides, leveraging its potential insecticidal and acaricidal properties to control pests in agricultural and other settings.

InChI:InChI=1/C11H15NO/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-5,11-12H,6-9H2

Upstream product

• 155989-69-8 tert-butyl 4-phenoxypiperidine-1-carboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 4783-86-2 4-phenoxypyridine 
• 100-39-0 benzyl bromide 
• 3112-85-4 methylphenylsulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 855267-34-4 3-(4-phenoxypiperidin-1-yl)propan-1-ol 
• 1025887-31-3 4-phenoxy-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-piperidine 
• 180157-22-6 (2S)-(-)-1-(4-indolyloxy)-3-(4-phenoxypiperidin-1-yl)-2-propanol ethanedioate 
• 639855-29-1 C₁₈H₂₂ClN₅O₂ 

Relevant academic research and scientific papers

Radical Anion Promoted Chemoselective Cleavage of Csp2-S Bond Enables Formal Cross-Coupling of Aryl Methyl Sulfones with Alcohols

A novel formal cross-coupling of aryl methyl sulfones and alcohols affording alkyl aryl ethers via an SRN1 pathway is developed. Two marketed antitubercular drugs were efficiently prepared employing this approach as the key step. A dimsyl-anion initiated radical chain process was revealed as the major pathway. DFT calculations indicate that the formation of a radical anion via nucleophilic addition of alkoxide to the aryl radical is the key step in determining the observed chemoselectivity.

6,5-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to 6,5-fused heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Synthesis of 11C-labelled ureas by palladium(II)-mediated oxidative carbonylation

Positron emission tomography is an imaging technique with applications in clinical settings as well as in basic research for the study of biological processes. A PET tracer, a biologically active molecule where a positron-emitting radioisotope such as carbon-11 has been incorporated, is used for the studies. Development of robust methods for incorporation of the radioisotope is therefore of the utmost importance. The urea functional group is present in many biologically active compounds and is thus an attractive target for incorporation of carbon-11 in the form of [11C]carbon monoxide. Starting with amines and [11C]carbon monoxide, both symmetrical and unsymmetrical 11C-labelled ureas were synthesised via a palladium(II)-mediated oxidative carbonylation and obtained in decay-corrected radiochemical yields up to 65%. The added advantage of using [11C]carbon monoxide was shown by the molar activity obtained for an inhibitor of soluble epoxide hydrolase (247 GBq/μmol-319 GBq/μ mol). DFT calculations were found to support a reaction mechanism proceeding through an 11C-labelled isocyanate intermediate.

Utility of azetidinium methanesulfonates for radiosynthesis of 3-[ 18F]fluoropropyl amines

3-Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat-induced cyclization of 3-methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [18F]fluoride (decay-corrected yields > 60%) efficiently, resulting in an efficient synthesis of 3-[18F] fluoropropyl tertiary amines. Copyright

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.

Dipeptides which promote release of growth hormone

Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis. STR1

Alkylenediamine derivatives

The present invention relates to alkylenediamine derivatives which relieve urinating contraction and therefore are of value as active ingredients of therapeutic agents for treating dysuria.

N-ALKYLENEPIPERIDINO COMPOUNDS, THEIR ENANTIOMERS AND PHARMACEUTICAL COMPOSITIONS

The invention relates to N-alkylenepiperidino compounds of formula STR1 as well as their enantiomers, and pharmaceutical compositions containing them that are useful as antagonists of neurokinin receptors in the treatment of substance P-and/or neurokinin-independent pathologies.