321-63-1

Basic information

• Product Name: 4'-FLUORO-BIPHENYL-2-YLAMINE
• Synonyms: 4'-FLUORO[1,1'-BIPHENYL]-2-AMINE;4'-FLUORO-BIPHENYL-2-YLAMINE;AKOS BAR-0108;2-AMINO-4'-FLUORODIPHENYL;4'-Fuorobiphenyl-2-ylamine;4'-Fluoro-biphenyl-2-aMine;[1,1'-Biphenyl]-2-amine,4'-fluoro-
• CAS NO: 321-63-1
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.21
• Mol File: 321-63-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 303.7±17.0 °C(Predicted)
• Appearance: /
• Density: 1.161±0.06 g/cm3(Predicted)
• PKA: 3.49±0.10(Predicted)
• CAS DataBase Reference: 4'-FLUORO-BIPHENYL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO-BIPHENYL-2-YLAMINE(321-63-1)
• EPA Substance Registry System: 4'-FLUORO-BIPHENYL-2-YLAMINE(321-63-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 321-63-1(Hazardous Substances Data)

Usage

General Description

4'-Fluoro-biphenyl-2-ylamine is a chemical compound that belongs to the class of biphenyl amines. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The presence of the fluorine atom in its structure makes it useful in drug discovery and development processes by enhancing the pharmacokinetic properties of the final products. 4'-FLUORO-BIPHENYL-2-YLAMINE has also been studied for its potential medical applications, particularly in the treatment of cancer and other diseases. It is important to handle 4'-fluoro-biphenyl-2-ylamine with caution due to its potential health hazards and toxic effects.

Upstream product

• 20893-71-4 4-fluorophenyldiazonium chloride 
• 62-53-3 aniline 
• 1416964-69-6 C₆H₄FN₂O^(1-)*Na⁽¹⁺⁾ 
• 371-40-4 4-fluoroaniline 
• 462-06-6 fluorobenzene 
• 100-63-0 phenylhydrazine 

Downstream Products

• 76838-55-6 N-benzoyl-N'-(4'-fluoro-2-biphenylyl)thiourea 
• 456-22-4 4-Fluorobenzoic acid 
• 942613-48-1 3,4-dichloro-N-(4'-fluoro-biphenyl-2-yl)-benzenesulfonamide 
• 1330574-28-1 ethyl 2-(8-fluoro-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate 
• 1312447-98-5 N-Ts-2-(4'-fluorophenyl)aniline 
• 942613-49-2 [5-(3,4-dichloro-benzenesulfonyl)-8-fluoro-5,6-dihydro-phenanthridin-6-yl]-acetic acid methyl ester 
• 1386928-23-9 1-[2-(4-fluorophenyl)phenyl]piperazine hydrochloride 
• 1435476-57-5 9-fluoro-6-methyl-6-phenyl-6,7-dihydro-5H-dibenzo[b,d]azepine 
• 391-53-7 2-fluoro-9H-carbazole 

Relevant articles and documents

Process for the Synthesis of Aminobiphenylene

The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

The gomberg-bachmann reaction for the arylation of anilines with aryl diazotates

Simply aqueous sodium hydroxide is sufficient to exclude ionic side reactions and to prepare 2-aminobiphenyls from aryl diazotates and anilines through a new variant of the Gomberg-Bachmann reaction (see scheme). The metal-free reaction under basic conditions allows to exploit the highly radical-stabilizing effect of the aniline's free amino function for the first time, which leads to a so far unreached regioselectivity. Copyright