321-63-1

Usage

Uses

Used in Pharmaceutical Industry:
4'-Fluoro-biphenyl-2-ylamine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to improve the pharmacokinetic properties of the final products. The presence of the fluorine atom in its structure allows for better absorption, distribution, metabolism, and excretion of the resulting drugs, leading to enhanced efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 4'-fluoro-biphenyl-2-ylamine serves as a key intermediate in the development of new pesticides and herbicides. Its unique chemical properties enable the creation of more effective and targeted agrochemicals, contributing to improved crop protection and yield.
Used in Drug Discovery and Development:
4'-Fluoro-biphenyl-2-ylamine is utilized in drug discovery and development processes as a building block for designing novel therapeutic agents. Its incorporation into drug molecules can enhance their pharmacokinetic properties, leading to improved drug candidates with better efficacy, safety, and pharmacological profiles.
Used in Cancer Treatment Research:
4'-Fluoro-biphenyl-2-ylamine has been studied for its potential applications in the treatment of cancer. Its unique structure and properties make it a promising candidate for the development of new anticancer drugs, which could target specific cancer cells and pathways, leading to more effective treatments with fewer side effects.

Upstream product

• 462-06-6 fluorobenzene 
• 100-63-0 phenylhydrazine 
• 20893-71-4 4-fluorophenyldiazonium chloride 
• 62-53-3 aniline 
• 1416964-69-6 C₆H₄FN₂O^(1-)*Na⁽¹⁺⁾ 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 456-22-4 4-Fluorobenzoic acid 
• 942613-48-1 3,4-dichloro-N-(4'-fluoro-biphenyl-2-yl)-benzenesulfonamide 
• 1435476-57-5 9-fluoro-6-methyl-6-phenyl-6,7-dihydro-5H-dibenzo[b,d]azepine 
• 76838-55-6 N-benzoyl-N'-(4'-fluoro-2-biphenylyl)thiourea 
• 1613547-38-8 (8‐fluorophenanthridin‐6‐yl)diphenylphosphine oxide 

Relevant academic research and scientific papers

Process for the Synthesis of Aminobiphenylene

The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

The gomberg-bachmann reaction for the arylation of anilines with aryl diazotates

Simply aqueous sodium hydroxide is sufficient to exclude ionic side reactions and to prepare 2-aminobiphenyls from aryl diazotates and anilines through a new variant of the Gomberg-Bachmann reaction (see scheme). The metal-free reaction under basic conditions allows to exploit the highly radical-stabilizing effect of the aniline's free amino function for the first time, which leads to a so far unreached regioselectivity. Copyright

The gomberg-bachmann reaction for the arylation of anilines with aryl diazotates

Simply aqueous sodium hydroxide is sufficient to exclude ionic side reactions and to prepare 2-aminobiphenyls from aryl diazotates and anilines through a new variant of the Gomberg-Bachmann reaction (see scheme). The metal-free reaction under basic conditions allows to exploit the highly radical-stabilizing effect of the aniline's free amino function for the first time, which leads to a so far unreached regioselectivity. Copyright

Reaction of phenylhydrazines with arenes in the presence of aluminium trichloride

Phenylnitrenium ions are generated from phenylhydrazines by treatment with AlCl3. Reaction of a phenylnitrenium ion with arenes results in both aromatic N-substitution and C-substitution. In contrast, an N-methylphenylnitrenium ion undergoes exclusively aromatic C-substitution. Reaction of a phenylnitrenium ion with arenes present only in slight excess produces anilinated products in moderate to good yields.