3213-94-3

Usage

Derivative of 1,2,4-Triazole

Indicates that the compound is derived from the parent compound 1,2,4-triazole, which is a heterocyclic organic compound.

Industrial and Chemical Processes

The compound is used in various industrial and chemical processes, such as pharmaceutical and agricultural chemical intermediates, and as a reagent in organic synthesis.

Pharmaceutical Intermediate

It serves as a building block or precursor in the synthesis of pharmaceutical compounds.

Agricultural Chemical Intermediate

It is used in the synthesis of agrochemicals, such as pesticides and fertilizers.

Reagent in Organic Synthesis

The compound acts as a reagent, facilitating specific chemical reactions in organic synthesis.

Potential Biological Activities

The compound has been studied for its possible biological activities, such as anti-inflammatory, antifungal, and anticancer properties.

Anti-inflammatory

It may help reduce inflammation in the body.

Antifungal

It may exhibit properties that inhibit the growth of fungi.

Anticancer

It has been investigated for its potential to inhibit or prevent the growth of cancer cells.

Low Toxicity

The compound is considered to have low toxicity, making it relatively safe to handle and use.

Safety Protocols

It is generally considered safe when handled and used according to standard safety protocols, such as wearing appropriate personal protective equipment and following proper disposal procedures.

Upstream product

• 7170-01-6 3-methyl-1H-[1,2,4]triazole 
• 104-87-0 4-methyl-benzaldehyde 
• 124-42-5 acetamidine hydrochloride 
• 6326-27-8 p-methylbenzamidine hydrochloride 
• 210179-03-6 4-methyl-benzoic acid N'-(1-imino-ethyl)-hydrazide 
• 1314991-79-1 4-methyl-benzoic acid (1-imino-ethyl)hydrazide 
• 19227-13-5 p-toluamidoxime 

Downstream Products

• 860025-98-5 [1,1-dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)propyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

TBHP/TBAI–Mediated simple and efficient synthesis of 3,5-disubstituted and 1,3,5-trisubstituted 1H-1,2,4-triazoles via oxidative decarbonylation of aromatic aldehydes and testing for antibacterial activities

The author has developed a simple, efficient and eco–friendly convenient general method for synthesis of 3,5–disubstituted–1,2,4–triazoles and 1,3,5–trisubstituted–1,2,4–triazoles from 3–monosubstituted–1,2,4–triazoles and 1,3–disubstituted–1,2,4–triazoles respectively using tetrabutylammonium iodide (TBAI) as catalyst and TBHP as oxidant under mid reaction conditions. This method provides structurally diverse 3,5–disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles in good to excellent yields. 3,5–Disubstituted 1,2,4–triazoes and 1,3,5––trisubstituted–1,2,4–triazoles derivatives are biologically and pharmaceutically active molecules, and therefore, this protocol could be of wide applications in medicinal chemistry and organic chemistry.

Synthetic method of asymmetric 1,2,4-triazole derivatives

The invention provides a synthetic method of asymmetric 1,2,4-triazole derivatives. The synthetic method comprises the following steps: mixing amidine compound hydrochloride, amidoxime compounds, copper oxide and potassium carbonate, adding an organic solvent, and carrying out heating reaction under the condition of stirring to obtain a product; drying, separating and purifying to obtain the asymmetric 1,2,4-triazole derivatives. Compared with the prior art, the synthetic method provided by the invention has the following advantages that firstly, the synthetic method is carried out in the air atmosphere, so that the cost is low; secondly, no precious metals, strong base and organic oxidants are used, while the copper oxide is used as a catalyst, so that the cost is reduced; thirdly, amidine and nitrile are used as reaction raw materials, and the raw materials are easily obtained; fourthly, the synthetic method is high in efficiency and wide in application range, and is suitable for multiple substrate reactions.

Copper-catalyzed synthesis of 1,2,4-triazoles via sequential coupling and aerobic oxidative dehydrogenation of amidines

A convenient, efficient, and practical copper-catalyzed one-pot method for the synthesis of 1,2,4-triazoles has been developed via reactions of amidines. The procedure underwent sequential base-promoted intermolecular coupling (nucleophilic substitution) between two amidines and intramolecular aerobic oxidative dehydrogenation, and the inexpensive, convenient, and efficient method for the synthesis of 1,2,4-triazoles will attract much attention in academic and industrial research. Georg Thieme Verlag Stuttgart · New York.

SINGLE ENANTIOMER BETA-AGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THE USE THEREOF AS MEDICATION

The present invention relates to single enantiomer compounds of formula (1), where the moieties n, A, R1, R2, R3, m, and Y can have the meanings stated in the claims and in the description, methods for the production there

SMALL MOLECULE MODULATORS OF CELL ADHESION

Compounds, particularly compounds having activity as modulators of cadherin-mediated cell adhesion having the following structure: or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein R1, R2, R3,

DRUG COMBINATIONS FOR THE TREATMENT OF RESPIRATORY TRACT DISEASES

The present invention relates to novel drug combinations which, besides one or more, preferably on compound of the general formula (1), wherein remainder n, A, R1, R2, and R3 can have the meanings given in the claims and in the description comprise at least one further active ingredient 2 and method for the production thereof and the use thereof as drugs.

Long-acting betamimetics for the treatment of respiratory complaints

The present invention relates to compounds of formula 1, wherein n, A, R1, R2 and R3 may have the meanings specified in the description and claims, processes for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.

3-Hydroxymethyl-4-hydroxy-phenyl-derivatives for the treatment of respiratory diseases

The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, X and Y may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of CO

New long acting beta-2 agonists and their use as medicaments

A compound of formula 1 wherein the groups R1, R2, R3, R4 and n may have the meanings given in the claims and in the specification, and methods for preparing a pharmaceutical composition for the treatment of inf

3-HYDROXYMETHYL-4-HYDROXY-PHENYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY ILLNESSES

The invention relates to the use of compounds of general formula 1 wherein the groups R1, X and Y have the designations cited in the claims and in the description, for producing a medicament for treating COPD (chronic obstructive pulmonary disease). The invention also relates to novel compounds of general formula 1, and to methods for the production thereof.