3221-25-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperazineethanol,4-ethyl-(7CI,8CI,9CI) is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its potential biological activity makes it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
1-Piperazineethanol,4-ethyl-(7CI,8CI,9CI) is used in the production of agrochemicals, contributing to the development of effective and innovative solutions for agriculture.
Used in Industrial Chemical Industry:
1-Piperazineethanol,4-ethyl-(7CI,8CI,9CI) is utilized in the production of industrial chemicals, showcasing its versatility and applicability in various chemical processes.
Used in Therapeutic Applications:
1-Piperazineethanol,4-ethyl-(7CI,8CI,9CI) is studied for its potential therapeutic effects in the treatment of various conditions, including depression, anxiety, and neurological disorders. Its potential biological activity makes it a promising candidate for further research and development in the medical field.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 74-96-4 ethyl bromide 
• 142-64-3 piperazine dihydrochloride 
• 5308-25-8 4-ethylpiperazine 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 

Downstream Products

• 141312-20-1 (2-Heptyloxy-phenyl)-carbamic acid 2-(4-ethyl-piperazin-1-yl)-ethyl ester; hydrochloride 

Relevant academic research and scientific papers

Selective, Catalytic, and Dual C(sp3)-H Oxidation of Piperazines and Morpholines under Transition-Metal-Free Conditions

By using cheap and innocuous reagents, such as NaClO2, NaOCl, and catalytic amounts of TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C(sp3)-H oxidation of piperazines and morpholines to 2,3-diketopiperazines (2,3-DKP) and 3-morpholinones (3-MPs), respectively, has been developed. This novel direct access to 2,3-DKP from piperazines provides significant advantages over the traditional N-monoacylation/intramolecular C-N cyclization procedure. Additionally, by modulating the amounts of TEMPO, 2-alkoxyamino-3-morpholinone can be prepared from morpholine derivatives, which would enable further functionalization at the C2 position of the morpholine skeleton.

Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism in Vivo

Three series of scutellarein derivatives have been designed and synthesized based on metabolic mechanism of scutellarin (1) in vivo. Their thrombin inhibition activities were tested through the analyzation of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB). The antioxidant activities of these target products were assessed by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay and the ability to protect PC12 cells against H2O2-induced cytotoxicity, and their solubilities were evaluated by ultraviolet (UV) spectrophotometer. The results showed that the two isopropyl groups substituted derivative (18c) demonstrated stronger anticoagulant activity, better water solubility, and good antioxidant activity compared with scutellarein (2), which warrants further development of 18c as a promising agent for ischemic cerebrovascular disease treatment. Three series of scutellarein derivatives have been designed and synthesized based on metabolic mechanism of scutellarin (1) in vivo. The results of the biological evaluation showed that the two isopropyl groups substituted derivative (18c) demonstrated stronger anticoagulant activity, better water solubility, and good antioxidant activity compared with scutellarein (2), which warrants further development of 18c as a promising agent for ischemic cerebrovascular disease treatment.

SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS

Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal