32211-97-5

Usage

Uses

Antidepressant.

InChI:InChI=1/C14H18N2/c1-16(2)10-7-8-14-12(9-10)11-5-3-4-6-13(11)15-14/h3-6,10,15H,7-9H2,1-2H3

Upstream product

• 40594-34-1 4-(dimethylamino)cyclohexanone 
• 100-63-0 phenylhydrazine 
• 176661-76-0 (1,4-dioxa-spiro[4.5]dec-8-yl)dimethylamine 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 1414847-41-8 N,N-dimethyl-[9-(2-bromobenzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine 
• 1414847-45-2 N,N-dimethyl-[9-(2-chlorobenzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine 
• 1414847-47-4 N,N-dimethyl-[9-(2-fluorobenzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine 
• 32212-04-7 9-(p-chlorobenzyl)-3-(dimethylamino)-1,2,3,4-tetrahydrocarbazole 

Relevant academic research and scientific papers

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.

Carbazole Derivatives as Functional 5-HT6 Ligands

The present invention provides carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT6 receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HT6 receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicines containing the said carbazole derivatives.

CARBAZOLE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS

The present invention provides carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT6 receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HT6 receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicines containing the said carbazole derivatives.

3-Hydroxy carbazole derivatives

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.

3-Amido-1,2,3,4-tetrahydrocarbazoles

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.