3223-77-6

Usage

Uses

Used in Chemical Synthesis:
2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE is used as a building block in the synthesis of other organic compounds, contributing to the development of new chemical entities with potential applications in various industries.
Used in Pharmaceutical Industry:
2-CHLORO-N-(4-METHOXY-2-NITRO-PHENYL)-ACETAMIDE may have biological and pharmacological properties, although further research is needed to fully understand its potential uses and effects. Its unique structure could make it a promising candidate for drug discovery and development, particularly in the areas of medicinal chemistry and pharmaceutical research.

Upstream product

• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 104-94-9 4-methoxy-aniline 
• 79-04-9 chloroacetyl chloride 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 861341-80-2 chloro-acetic acid-(4-methoxy-2,3-dinitro-anilide) 
• 861797-58-2 chloro-acetic acid-(4-methoxy-2,5-dinitro-anilide) 
• 96-96-8 4-methoxy-2-nitroaniline 
• 1206903-37-8 C₃₅H₅₈N₆O₁₀ 
• 2574-01-8 piperidino-acetic acid-(2-amino-4-methoxy-anilide) 
• 5473-00-7 4-methoxy-2,3-dinitro-aniline 
• 97457-75-5 3-Hydroxy-benzo[b]thiophene-2-carboxylic acid (4-methoxy-2-nitro-phenyl)-amide 
• 2718-19-6 piperidino-acetic acid-(4-methoxy-2-nitro-anilide) 

Relevant academic research and scientific papers

Synthesis, molecular docking and α-glucosidase inhibition of 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-N-arylacetamides

A novel series of 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-N-arylacetamides 5a–5q have been synthesized and evaluated for their α-glucosidase inhibitory activity. All newly synthesized compounds exhibited potent α-glucosidase inhibitory activity in the range of IC50?=?12.46?±?0.13–72.68?±?0.20?μM, when compared to the standard drug acarbose (IC50?=?817.38?±?6.27?μM). Among the series, compound 5j (12.46?±?0.13?μM) with strong electron-withdrawing nitro group on the arylacetamide moiety was identified as the most potent inhibitor of α-glucosidase. Molecular docking study was carried out to explore the binding interactions of these compounds with α-glucosidase. Our study identifies a novel series of potent α-glucosidase inhibitors for further investigation.

Sensitized lanthanide-ion luminescence with aryl-substituted N-(2-nitrophenyl)acetamide-derived chromophores

The syntheses of the two tetraazamacrocyclic ligands L1 and L2 bearing a [(methoxy-2-nitrophenyl)amino]carbonyl chromophore, i.e., an N-(methoxy-2-nitrophenyl)acetamide moiety, together with their corresponding lanthanide-ion complexes are described. A combined spectroscopic (UV/VIS, 1H-NMR), structural (X-ray), and theoretical (DFT) investigation revealed that the absorption properties of the chromophores were dictated by the extent of electronic delocalisation, which in turn was determined by the position of the MeO substituent at the aromatic ring. X-Ray crystallographic studies showed that when attached to the macrocycle, both isomeric forms of the N-(methoxy-2-nitrophenyl)acetamide unit can participate in coordination, via the C=O, to an encapsulated potassium cation. Luminescence measurements confirmed that such a binding mode also exists in solution for the corresponding lanthanide complexes (q ca. ≤1), with the para-MeO derivative allowing longer wavelength sensitization (λex 330 nm).

Activities of 2-carboxanilido 3-hydroxybenzo[b]thiophens against molluscs Biomphalaria

The title compounds are shown to be nearly as active against molluscs as Niclosamide when they are either dihalogenated or monohalogenated and mononitrated on the benzene ring.