32322-73-9

Usage

Uses

Used in Organic Synthesis:
N-(SEC-BUTYL)-2-CHLOROACETAMIDE is used as a building block in organic synthesis for the preparation of various compounds. Its unique structure, featuring a sec-butyl group and a chlorine atom, allows for the creation of diverse chemical entities with potential applications in different industries.
Used in Chemical Research:
In the field of chemical research, N-(SEC-BUTYL)-2-CHLOROACETAMIDE serves as a valuable compound for studying the properties and reactions of amides and related organic compounds. Its reactivity and structural features make it a useful tool for understanding the behavior of similar compounds and developing new synthetic methods.
Used in Pharmaceutical Industry:
N-(SEC-BUTYL)-2-CHLOROACETAMIDE may have potential applications in the pharmaceutical industry as a precursor or intermediate in the synthesis of drug molecules. Its unique structural features could contribute to the development of new therapeutic agents with specific pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical industry, N-(SEC-BUTYL)-2-CHLOROACETAMIDE could be utilized as a starting material or intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its potential reactivity and structural diversity may lead to the development of novel and effective products for agricultural use.

Upstream product

• 33966-50-6 SEC-BUTYLAMINE 
• 79-04-9 chloroacetyl chloride 
• 7572-29-4 dichloroethyne 
• 78-81-9 isobutylamine 

Relevant academic research and scientific papers

GLUCOSE UPTAKE INHIBITORS

Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.

TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS

Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands-A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy3+, Tb3+, and Tm3+) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with corresponding N-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37 C, revealing that Tm3+-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.

REACTIONS OF DICHLOROACETYLENE WITH PRIMARY ALIPHATIC AMINES

Primary aliphatic amines are good nucleophilic reagents which easily react with dichloroacetylene (DCA).The reactions of DCA with primary aliphatic amines have been studied and a mechanism of these reactions has been proposed and discussed.