32391-97-2

Basic information

• Product Name: 4-(methylsulfanyl)butanoic acid
• Synonyms: butanoic acid, 4-(methylthio)-
• CAS NO: 32391-97-2
• Molecular Formula: C₅H₁₀O₂S
• Molecular Weight: 134.1967
• Mol File: 32391-97-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 269.6°C at 760 mmHg
• Flash Point: 116.9°C
• Density: 1.121g/cm³
• Vapor Pressure: 0.00203mmHg at 25°C
• Refractive Index: 1.492
• CAS DataBase Reference: 4-(methylsulfanyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methylsulfanyl)butanoic acid(32391-97-2)
• EPA Substance Registry System: 4-(methylsulfanyl)butanoic acid(32391-97-2)

Safety Data

• Hazardous Substances Data: 32391-97-2(Hazardous Substances Data)

Upstream product

• 96-48-0 4-butanolide 
• 108-88-3 toluene 
• 5188-07-8 sodium thiomethoxide 
• 628-20-6 4-Chlorobutyronitrile 
• 74-93-1 methylthiol 
• 35638-70-1 lithium methanethiolate 
• 13095-73-3 4-mercaptobutyric acid 
• 74-88-4 methyl iodide 
• 625-38-7 but-3-enoic acid 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 859200-50-3 (2-methylsulfanyl-ethyl)-malonic acid 

Downstream Products

• 22014-48-8 ethyl 4-(methylthio)butanoate 
• 5342-81-4 4-methanesulfonyl-butyric acid ethyl ester 
• 29431-37-6 tetrahydrothiopyran-3-one-1,1-dioxide 
• 637337-64-5 (4R)-3-[(2S)-2-({[(benzyloxy)carbonyl]amino}methyl)-4-(methylsulfanyl)-1-oxobutyl]-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 671233-56-0 (R)-4-isopropyl-3-((S)-2-{[(methoxycarbonyl)amino]methyl}-4-(methylsulfanyl)-1-oxobutyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one 
• 637337-73-6 (S)-2-({[(benzyloxy)carbonyl]amino}methyl)-4-(methylsulfanyl)butanoic acid 
• 658057-69-3 2-((6-chloropyridin-3-yl)methyl)-4-(methylsulfanyl)butyric acid phenyl ester 
• 658057-68-2 4-(methylsulfanyl)butyric acid phenyl ester 
• 637337-48-5 (R)-4-isopropyl-3-(4-methylsulfanyl-1-oxobutyl)-5,5-diphenyloxazolidin-2-one 
• 107-92-6 butyric acid 

Relevant articles and documents

Neighboring-Group Participation in Organic Redox Reactions. 10. The Kinetic and Mechanistic Effects of Imidazole and Benzimidazole Nitrogen on Thioether Oxidations

The kinetics of the aqueous iodine oxidation of a number of imidazolyl- and benzimidazolylalkyl methyl sulfides have been studied.Evidence of neighboring-group participation has been observed in all cases.The anchimeric assistance provided by the benzimidazole moiety is evidenced by rate accelerations of 102-105.The oxidation of 1-methyl-2-imidazole, 1, is 106 times faster than that of simple thioethers and is faster than any previously reported acyclic thioether.The reaction of 2-benzimidazole is accelerated by105 via a transient N-S dication.Additionally, the pH profiles of all of the compounds studied provide strong evidence for N-S interacted intermediates.

Development of 11C-Labeled ω-sulfhydryl fatty acid tracer for myocardial imaging with PET

[11C]-S-methyl-16-thiopalmitic acid (a) was developed with excellent heart-to-background uptake ratios and higher retention in heart. Myocardial uptake and metabolism of the tracer is markedly higher CPT I dependent. When compared to [11C]-S-methyl-14-thiomyristic acid (b), [11C]-S-methyl-12-thiododecanoic acid (c) and [11C]-palmitate, a showed an early high uptake and a significantly slower late clearance in heart and a prolonged myocardial elimination half-life (30 min). Analysis of heart tissue and urine samples showed that a was metabolized via beta-oxidation in myocardium. Small animal PET images of the accumulation of a in the rat myocardium were clearly superior to [11C]-palmitate. These initial studies suggest that a could be a potentially useful clinical PET tracer to assess myocardial fatty acid metabolism.

8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides

This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.