32394-82-4Relevant academic research and scientific papers
Microwave-assisted solvent-free and catalyst-free Kabachnik-Fields reactions for α-amino phosphonates
Mu, Xue-Jun,Lei, Mao-Yi,Zou, Jian-Ping,Zhang, Wei
, p. 1125 - 1127 (2006)
A highly efficient solvent-free and catalyst-free method for the synthesis of α-amino phosphonates is developed by a microwave-assisted three-component Kabachnik-Fields reaction involving aldehyde, amine, and dimethyl phosphite.
The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase
Chen, Zexin,Marcé, Patricia,Resende, Ricardo,Alzari, Pedro M.,Frasch, A. Carlos,van den Elsen, Jean M.H.,Crennell, Susan J.,Watts, Andrew G.
, p. 25 - 33 (2018/09/13)
The trans-sialidase protein expressed by Trypanosoma cruzi is an important enzyme in the life cycle of this human pathogenic parasite and is considered a promising target for the development of new drug treatments against Chagas' disease. Here we describe
Highly efficient solvent free synthesis of α-aminophosphonates catalyzed by recyclable nano-magnetic sulfated zirconia (Fe3O4@ZrO2/SO42-)
Ghafuri, Hossein,Rashidizadeh, Afsaneh,Esmaili Zand, Hamid Reza
, p. 16046 - 16054 (2016/02/19)
In this project, nano-magnetic sulfated zirconia Fe3O4@ZrO2/SO42- was prepared and characterized using various instrumental methods. Sulfated zirconia supported on magnetic nanoparticles can act as a well-organized nanocatalyst and can be easily separated from the reaction mixture using an external magnetic field. Nano-Fe3O4@ZrO2/SO42- is a heterogeneous acidic catalyst and has particular advantages such as a facile synthesis procedure, high activity, easy separation and reusability. It was applied as an efficient nanocatalyst in the synthesis of α-aminophosphonate derivatives in the Kabachnik-Fields reaction. This synthetic method has several advantages including high yields, short reaction times, easy workup and environmentally benign reaction conditions.
Highly efficient one-pot multi-component synthesis of α- aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis
Mulla, Shafeek A. R.,Pathan, Mohsinkhan Y.,Chavan, Santosh S.,Gample, Suwara P.,Sarkar, Dhiman
, p. 7666 - 7672 (2014/02/14)
A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of α- aminophosphonate derivatives (4a-x) in excellent yields. The α-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.
